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En nuestro laboratorio investigamos los mecanismos moleculares encargados de establecer la homeostasis iónica, redox y metabólica en células vivas. Nuestro enfoque experimental consiste en monitorear cambios en la fluorescencia de biosensores y sondas que nos informan de fluctuaciones en parámetros intracelulares que describen la actividad celular. Bajo esta modalidad podemos conocer el impacto biológico de compuestos dietarios no solo en células vivas sino que también en arreglos celulares que se comportan como una barrear intestinal.

Grado Académico
  • Doctor en Ciencias Biomédicas, Universidad de Chile, 2006
  • Bioquímico, Universidad de Chile, 2000
Unidad Académica

Nutrición Básica

Áreas de interés
  • Enfermedades cardiovasculares
  • Fisiología celular
  • Metabolismo celular
Publicaciones
2018 Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, Del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R. Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. Mol Cell Endocrinol. 2018; 461:277-283
2017 Tobar N, Porras O, Smith PC, Barros LF, Martínez J. Modulation of mammary stromal cell lactate dynamics by ambient glucose and epithelial factors. J Cell Physiol 2017; 232(1):136-144
2017 Kallens V, Tobar N, Molina J, Bidegain A, Smith PC, Porras O, Martínez J. Glucose promotes a pro-oxidant and pro-inflammatory stromal microenvironment which favors motile properties in breast tumor cells. J Cell Biochem 2017; 118(5):994-1002
2017 Román F, Urra C, Porras O, Pino AM, Rosen CJ, Rodríguez JP. Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women. J Cell Biochem. 2017; 118(3):585-593
2011 Porras O, Stutzin A. Glutamate-induced astrocytic metabolism influences the cytosolic redox state in hippocampal neurons. Biochem Biophys Res Commun 2011; 411(1):82-87
2011 Lilja A, Porras O, Storelli E, Nordberg A, Marutle A. Amyloid aggregation is critical for the interaction with neuronal nicotinic acetylcholine receptor subtypes: Implications for neuroprotection in Alzheimer´s disease. J Alzheimer Dis 2011; 23(2):335-347
2011 Keller C, Kadir A, Forsberg A, Porras O, Nordberg A. Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer’s disease patients. J Alzheimer Dis 2011; 24(1):109-123
2011 Nuñez-Villena F, Becerra A, Echeverría C, Briceño N, Porras O, Armisén R, Varela D, Montorfano I, Sarmiento D, Simon F. Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death. Antioxid Redox Signal 2011; 15(9):2425-2438
2010 Nilbratt M, Porras O., Marutle A, Hovatta O, Nordberg A. Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. J Cell Mol Med 2010; 14(6B):1476-1484
2008 Porras O, Ruminot I, Loaiza A, Barros LF. Na+-Ca2+ co-signaling in the stimulation of the glucose transporter Glut1 in cultured astrocytes. Glia 2008; 56:59-68
2007 Matus S, Burgos PV, Bravo-Zehnder M, Kraft R, Porras OH, Farías P, Barros LF, Torrealba F, Massardo L, Jacobelli S, González A. Antiribosomal-P auto antibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Méd 2007; 204:3221-3234
2007 Barros LF, Bittner CX, Loaiza A, Porras OH. A quantitative overview of glucose dynamics in the gliovascular unit. Glia 2007; 55:1222-1237
2006 Castro J, Ruminot I, Porras OH, Flores CM, Hermosilla T, Verdugo E, Hartel S, Michea L, Barros LF. ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload. Cell Death Differ 2006; 13:1675-1685
2005 Barros LF, Porras OH, Bittner CX. Why glucose transport in the brain matters for PET. Trends Neurosci 2005; 28:117-119
2004 Porras OH, Loaiza A, Barros LF. Glutamate mediates acute glucose transport inhibition in hippocampal neurons. J Neurosci 2004; 24:9669-9673
2003 Loaiza A, Porras OH, Barros LF. Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy. J Neurosci 2003; 23:7337-7342
2002 Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LG, Foufelle F, Carling D, Hardie DG, Baldwin SA. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci 2002; 115:2433-2442
2001 Barros LF, Barnes K, Ingram JC, Castro J, Porras O.H., Baldwin SA. Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells. Pflügers Arch 2001; 442:614-621
2000 Quintanilla RA, Porras OH, Castro J, Barros LF. Cytosolic [Ca2+] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells. Cell Calcium 2000; 28:97-106
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