Ana María Ronco Macchiavello

  • Académico
  • Profesor Titular
Cargo: Directora de la Escuela de Postgrado
Área :
  • Docencia
Ver perfil Uchile

Ana María Ronco Macchiavello

  • Académico
  • Profesor Titular

Directora de Escuela de Postgrado

Mis principales líneas de Investigación son :

  1. Reprogramación fetal
  2. Nutrición y Epigenética
  3. Folatos y vitamina B12
  4.  Desarrollo y crecimiento fetal
Grado Académico
  • Doctor en Ciencias mención Biología; Universidad de Chile, 1992
  • Licenciado en Bioquímica, Bioquímico, Universidad de Chile, 1976
Unidad Académica

Nutrición Humana

Áreas de interés
  • Exposición prenatal a metales pesados
  • Mecanismos epigenéticos
  • Origenes tempranos del desarrollo de patologia cardiovascular
2017 Castaño E, Caviedes L, Hirsch S, Llanos M, Iñiguez G, Ronco AM. Folate transporters in placentas from preterm newborns and their relation to cord blood folate and vitamin B12 levels. PLoS One. 2017 Jan 19;12(1):e0170389
2017 Sanchez H, Hossain MB, Lera L, Hirsch S, Albala C, Uauy R, Broberg K, Ronco AM. High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74
2016 Caviedes L, Iñiguez G, Hidalgo P, Castro JJ, Castaño E, Llanos M, Hirsch S, Ronco AM. Relationship between folate transporters expression in human placentas at term and birth weights. Placenta 2016; 38:24-28
2015 Penailillo R, Guajardo A, Llanos M, Hirsch S, Ronco AM. Folic acid supplementation during pregnancy induces sex-specific changes in methylation and expression of placental 11β-hydroxysteroid dehydrogenase 2 in rats. PLoS One 2015; 10(3):e0121098
2015 Rodriguez M, Miranda D, Bunout D, Ronco AM, de la Maza MP, Hirsch S. Folates induce colorectal carcinoma HT29 cell line proliferation through notch1 signaling. Nutr Cancer 2015; 67(4):706-711
2014 Castro F, Harari F, Llanos M, Vahter M, Ronco AM. Maternal-child transfer of essential and toxic elements through breast milk in a mine-waste polluted area. Am J Perinatol 2014; 31(11):993-1002
2013 Hirsch S, Miranda D, Muñoz E, Montoya M, Ronco AM, De la Maza MP, Bunout D. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition 2013; 29(5):772-776
2012 Zepeda R, Castillo P, Sáez D, Llanos MN, Ronco AM. Cardiac tissue injury resistance during myocardial infarction at adulthood by developmental exposure to cadmium. Cardiovasc Toxicol 2012; 12(1):64-72
2012 Castillo P, Ibáñez F, Guajardo A, Llanos MN, Ronco AM. Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus. PLoS One 2012; 7(9):e44139
2012 Harari F, Ronco AM, Concha G, Llanos M, Grandér M, Castro F, Palm B, Nermell B, Vahter M. Early-life exposure to lithium and boron from drinking water. Reprod Toxicol 2012; 34(4):552-560
2011 Valenzuela CA, Castillo VA, Aguirre C, Ronco AM, Llanos MN. The CB1 receptor antagonist SR141716A reverses adult male mice overweight and metabolic alterations induced by early stress. Obesity (Silver Spring) 2011; 19(1):29-35
2011 Ronco AM, Montenegro M, Castillo P, Urrutia M, Saez D, Hirsch S, Zepeda R, Llanos MN. Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring. Toxicol Appl Pharmacol 2011; 251(2):137-145
2010 Lardone MC, Castillo P, Valdevenito R, Ebensperger M, Ronco AM, Pommer R, Piottante A, Castro A. P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure. Int J Androl 2010;33(4):650-660
2010 Ronco AM, Llaguno E, Epuñan MJ, Llanos MN. Effect of cadmium on cortisol production and 11beta-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3).Toxicol In Vitro 2010; 24(6):1532-1537
2010 Ronco AM, Gutierrez Y, Gras N, Muñoz L, Salazar G, Llanos MN. Lead and arsenic levels in women with different body mass composition. Biol Trace Elem Res 2010; 136(3):269-278
2009 Ronco AM, Urrutia M, Montenegro M, Llanos MN. Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids. Toxicol Lett 2009; 188(3):186-191
2009 Llanos MN, Ronco AM. Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities. Reprod Toxicol 2009; 27(1):88-92
2008 Hirsch S, Ronco AM, Guerrero-Bosagna C, De la Maza MP, Leiva L, Barrera G, Llanos M, Alliende MA, Silva F, Bunout D. Methylation status in healthy subjects with normal and high serum folate concentration. Nutrition 2008; 24(11-12):1103-1109
2008 Hirsch S, Ronco AM, Pinardi G, Montequin MJ, Leiva L, De la Maza MP, Llanos M, Bunout D. Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats. Clin Nutr 2008; 27(6):895-899
2007 Ronco AM, Llanos M, Tamayo D, Hirsch S. 5-Methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells. Nutr Metab Cardiovasc Dis 2007; 17:188-194
2007 Ronco AM, Llanos M, Tamayo D, Hirsch S. Anandamide inhibits endothelin-1 production by human cultured endothelial cells: A new vascular action of this endocannabinoid. Pharmacology 2007; 79(1):12-16
2006 Ronco AM, Garrido F, Llanos MN. Smoking specifically induces metallothionein-2 isoform in human placenta at term. Toxicology 2006; 223(1-2):46-53
2006 Valenzuela A, Ronco AM. Los fitoesteroles: Lípidos de origen natural que protegen la salud (Phytosterols: natural lipids that protect health). Aceites & Grasas 2006; 14(4):560-567
2005 Ronco AM, Arguello G, Suazo M, Llanos MN. Increased levels of metallothionein in placenta of smokers. Toxicology 2005; 208(1):133-139
2005 Ronco AM, Arguello G, Muñoz L, Gras N, Llanos M. Metals content in placentas from moderate cigarette consumers: correlation with newborn birth weight. Biometals 2005; 18(3):233-241
2005 Ronco AM, Garrido A, Llanos MN, Guerrero-Bosagna C, Tamayo D, Hirsch S. Effect of homocysteine, folates, and cobalamin on endothelial cell- and copper-induced LDL oxidation. Lipids 2005; 40(3):259-264
2004 Hirsch S, Ronco AM, Vazquez M, De La Maza MP, Garrido A, Barrera G, Gattas V, Glasinovic A, Leiva L, Bunout D. Hyperhomocysteinemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress. J Nutr 2004; 134(7):1832-1835
2003 Llanos M, Ronco AM, Aguirre MC. Specific strynchnine binding sites on acrosome-associated membranes of golden hamster spermatozoa. Biochem Biophys Res Commun 2003; 306(2):376-381
2002 Ronco AM, Moraga P, Llanos M. Arachidonic acid release from rat Leydig Cells. The involvement of G protein, phospholipase A2 and regulation of cAMP production. J Endocrinol 2002; 172 (1):95-104
2001 Llanos M, Ronco AM, Aguirre MC, Meizel S. Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction. Mol Reprod Dev 2001; 58:205-215
2001 Ronco AM, Valdes K, Marcus D, Llanos M. The mechanism for lindane-induced inhibition of steroidogenesis in cultured rat Leydig cells. Toxicology 2001; 159:99-106
2000 Suwalsky M, Villena F, Marcus D, Ronco AM. Plasma absorption and ultrastructural changes of rat testicular cells induced by lindane. Human Exp Toxicol 2000; 19:529-533
2000 Ronco AM, Llanos M. Effect of human chorionic gonadotropin derivatives on Leydig cell function. Horm Res 2000; 54:157-163
1998 Ronco AM, Tijmes M, Santibañez JF, Moraga P. Effect of desialysated human chronionic gonadotropin hGC on the bioactivity of rat Leyding cells. Cell Biochem Function 1998; 16:21-28
1998 Ronco AM, Contreras H. 3B-hydroxysteroid dehydrogenase (3B-HSD) activity in individual rat Leydig cells. Adv Reprod 1998; 1(1):17-26
1998 Ronco AM, Marcus D, Villena F, Suwalsky M. In vitro effect of dieldrin on Leydig cell morphology and steroidogenic function. In Vitro Mol Toxicol 1998; 11:(4):299-307
1997 Moraga P, Llanos M, Ronco AM. Arachidonic acid release from rat Leydig cells depends on the presence of luteinizing hormone/human chorionic gonadotrophin receptors. J Endocrinol 1997; 154:201-209
1994 Llanos M, Ronco AM. Sperm phospholipid methyltransferase activity during preparation for exocytosis. Cell Biochem Funct 1994; 12:289-296
1994 Contreras H, Ronco AM. Leydig cell heterogeneity as judged by quantitative cytochemistry of 3ß-hydroxysteroid dehydrogenase activity in individual rat Leydig cells. J Steroid Biochem Mol Biol 1994; 51(1-2):73-79
1993 Ronco AM, Llanos M, Valladares L. Human chorionic gonadotropin and free beta molecules stimulate phospholipid methylation in intact rat Leydig cells. Steroids 1993; 58:314-319
1993 Ronco AM, Valladares L. Phospholipid methylation decreases in hCG-induced desensitized rat Leydig cells. J Endocrinol 1993; 138:65-71
1992 Ronco AM, Valladares L, Devoto L, Ahumada A, Pino AM. In vitro effect of hCG on steroidogenesis on the testicular tissue from a patient with complete androgen resistance. J Endocrinol Invest 1992; 15:683-687
1992 Ronco AM, Valladares L. The effect of hCG-induced desensitization on RNA synthesis in rat Leydig cells. Biochem Int 1992; 27:65-74
1988 Ronco AM, Pino AM, Valladares L. RNA aynthesis in the Leydig cells of the mature rat: effect of oestradiol-17B. J Endocrinol 1988; 116:387-392
1986 Valladares L, Ronco AM, Pino AM. RNA synthesis in Leydig cells during sexual maturation in the rat: effect of LH. J Endocrinol 1986; 110:551-556
1985 Llanos M, Ronco AM, Pino AM, Valladares L. The transmethylations inhibitor 3-deazaadenosine, inhibits in vitro testosterone production by rat testis interstitial cell stimulated with HCG. J Steroid Biochem 1985; 23:73-76
1984 Valladares LE, Ronco AM. Effect of luteinizing hormone on RNA synthesis in Leydig cells of immature rats. J Steroid Biochem. 1984 Oct;21(4):443-6
1981 Perretta M, Waissbluth L, Ludwig U, Garrido F, Garrido A, Ronco AM. Different RNA species stimulated by testosterone and erythropoietin in isolated bone marrow nuclei obtained from polycythemic and anemic rats. J Steroid Biochem. 1981 Jun;14(6):537-43
2017 Castaño E, Piñuñuri R, Hirsch S, Ronco AM. Folato y embarazo, conceptos actuales. ¿Es necesario una suplementación con ácido ascórbico? (Folate and pregnancy, current concepts. It is required folic acid supplementation?). Rev Chil Pediatr. 2017; 88(2):199-206
2014 Pizarro S, Ronco AM, Gotteland M. β-glucanos: ¿Qué tipos existen y cuáles son sus beneficios en la salud? (β-glucans: What types exist and what are their health benefits? Rev Chil Nutr 2014; 41(4):439-446
2014 Valenzuela C, Castillo V, Ronco AM, Aguirre C, Hirsch S, Llanos M. Sistema endocanabinoide y desarrollo de esteatosis hepática (A role for the endocannabinoid system in hepatic steatosis). Rev Méd Chil 2014; 142(3):353-360
2011 Pacheco R, Bay C, Gutiérrez Y, Salazar G, Muñoz L, Llanos M, Ronco AM. Contenido de plomo sanguíneo y composición corporal en mujeres jóvenes expuestas a humo de madera en la ciudad de Temuco (Blood lead levels and body composition in young women exposed to wood smoke in the city of Temuco). Rev Chil Nutr 2011; 38(4): 414-421
2010 Valenzuela C, Aguirre C, Castillo V, Ronco AM, Llanos M. Participación del sistema endocanabinoide en el desarrollo de obesidad (A role for the endocannabinoid system in obesity). Rev Med Chil 2010;138(5):621-629
2004 Valenzuela A, Ronco AM. Fitoesteroles y fitoestanoles: aliados naturales para la protección de la salud cardiovascular (Phytosterols and phytostanols: natural allied for the protection of cardiovascular health). Rev Chil Nutr 2004; 31(Supl 1):161-169
2001 Ronco AM, Llanos M, Valladares L, Garrido A. Riesgo potencial para la salud humana de los xenobióticos ambientales como moduladores endocrinos (Potential health risks of environmental xenobiotics as endocrine modulators). Rev Chil Nutr 2001; 28(3):406-413
1999 Ronco AM, Llanos M, Valladares L. Anabólicos en producción pecuaria: un riesgo para la salud del consumidor? (Use of anabolics in livestock: a health risk for the consumer?). Rev Chil Nutr 1999; 26:288-294
1999 Ronco AM, Llanos M, Valladares L. Anabólicos en producción pecuaria: un riesgo para la salud del consumidor? (Use of anabolics in livestock: a health risk for the consumer?). Rev Chil Nutr 1999; 26:288-294
1996 Estay FJ, Ronco AM, Caceres LG. Respuesta ovulatoria y niveles séricos de GtH II alcanzados en hembras de trucha arco iris (Oncorhynchus mykiss) inducidas a ovular con GnRHa-D-Ala (Ovulatory response and GtH II serum levels in female rainbow trout (Oncorhynchus mykiss) with GnRHa-Ala induced ovulation). Arch Med Vet 1996; 28(2):73-79
1995 Ronco AM, Estay F, Rosselot G, Caceres L. Determination of circulating maturational gonadotropin (gth ii) in rainbow trout (Oncorhynchus mykiss) using a heterologous radioimmunoassay). Biol Res 1995; 28:301-306
1993 Vera H, Tijmes M, Ronco AM, Valladares L. Melatonin binding sites in interstitial cells from immature rat testes. Biol Res 1993; 26:337-340
1984 Valladares L. Ronco AM, Pino AM. Acción del estradiol en la regulación de la esteroidogenesis testicular (Action of stradiol on the regulation of testicular steroidogenesis). Rev Med Chil 1984; 112(6):599-603

Ingresa tu búsqueda y presiona [enter] o el botón "Buscar"