Arredondo Olguín Miguel Armando

Profesor Titular
Unidad Académica: 
(56) 229781483
Grado Académico: 
Doctor en Ciencias, Universidad de Chile
Magíster en Ciencias Biológicas, Universidad de Chile
Áreas de Interés: 
Metabolismo Intracelular de metales trazas y su asociación con enfermedades cardiovasculares y obesidad

•       Tecnólogo Médico (Universidad de Chile, 1983).
•       Magíster en Ciencias Biológicas (Universidad de Chile, 1996)
•       Becado por un año en el laboratorio del Dr. Jonathan Glass en Louisiana State University Medical Center (LSUMC), Shreveport, USA.
•       Doctor en Ciencias (Universidad de Chile, 2002)
•       Desde 1994, Académico del Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, donde actualmente es Profesor Titular.

•       Coordinador del Comité de Doctorado en Nutrición y Alimentos
•       Jefe del Laboratorio de Micronutrientes
•       Autor de numerosas publicaciones internacionales y nacionales (Total 81), principalmente en metabolismo intracelular de hierro y cobre y su asociación con enfermedades cardiovasculares, diabetes y obesidad
•       Investigador en numerosos proyectos de Investigación: 10 en calidad de Investigador Principal y 32 como Co-Investigador. Financiados con fondos tanto Nacionales como Internacionales

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2017 García MI, De la Parra A, Arias C, Arredondo M, Cabello JF. Long-term cognitive functioning in individuals with tyrosinemia type 1 teeated with nitisinone and protein-restricted diet. Mol Genet Metab Rep 2017; 11:12-16
2017 Weinborn V, Valenzuela C, Olivares M, Arredondo M, Weill R, Pizarro F. Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans. Food Funct. 2017 May 24; 8(5):1994-1999
2017 Mujica V, Orrego R, Pérez J, Romero P, Ovalle P, Zúñiga-Hernández J, Arredondo M, Leiva E. The role of propolis in oxidative stress and lipid metabolism: A randomized controlled trial. Evid Based Complement Alternat Med. 2017; 2017:4272940
2016 Pizarro F, Olivares M, Valenzuela C, Brito A, Weinborn V, Flores S, Arredondo M. The effect of proteins from animal source foods on heme iron bioavailability in humans. Food Chem 2016; 196:733-738
2016 Andrews M, Leiva E, Arredondo M. Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus. J Trace Elem Med Biol. 2016; 37:25-30
2015 Andrews M, Arredondo M, Olivares M. Glycemic control and oxidative stress markers and their relationship with the thioredoxin interacting protein (TXNIP) gene in type 2 diabetic patients. Nutr Hosp 2015; 31(3):1129-1133
2015 Weinborn V, Pizarro F, Olivares M, Brito A, Arredondo M, Flores S, Valenzuela C. The effect of plant proteins derived from cereals and legumes on heme iron absorption. Nutrients 2015; 7(11):8977-8986
2015 Jaramillo A, Briones L, Andrews M, Arredondo M, Olivares M, Brito A, Pizarro F. Effect of phytic acid, tannic acid and pectin on fasting iron bioavailability both in the presence and absence of calcium. J Trace Elem Med Biol 2015; 30:112-117
2014 Andrews M, Briones L, Jaramillo A, Pizarro F, Arredondo M. Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro caco-2 cell model. Biol Trace Elem Res 2014; 158(1):122-127
2014 Arredondo M, Mendiburo MJ, Flores S, Singleton ST, Garrick MD. Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells. Biometals 2014; 27(1):115-123
2014 Espinoza A, Morales S, Arredondo M. Effects of acute dietary iron overload in pigs (Sus scrofa) with induced type 2 Diabetes Mellitus. Biol Trace Elem Res 2014; 158(3):342-352
2014 Leiva E, Mujica V, Orrego R, Wehinger S, Soto A, Icaza G, Vásquez M, Díaz L, Andrews M, Arredondo M. Subjects with impaired fasting glucose: evolution in a period of 6 years. J Diabetes Res 2014; 2014:710370
2014 Andrews M, Arredondo M. Relación entre ferritina, PCRrus y expresion de hepcidina con el riesgo de desarrollo de diabetes mellitus tipo 2 en sujetos obesos (Association between ferritin, high sensitivity c-reactive protein (hsCRP) and relative abundance of Hepcidin mRNA with the risk of type 2 diabetes in obese subjects). Nutr Hosp 2014; 30(3):577-584
2014 Arredondo M, Weisstaub SG, Medina M, Suazo M, Guzmán M, Araya M. Assessing chaperone for Zn, Cu-superoxide dismutase as an indicator of copper deficiency in malnourished children. J Trace Elem Med Biol 2014; 28(1):23-27
2014 Araya M, Gutiérrez R, Arredondo M. CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes. Biometals 2014; 27(4):645-652
2013 Leiva E, Mujica V, Sepúlveda P, Guzmán L, Núñez S, Orrego R, Palomo I, Andrews M, Arredondo MA High levels of iron status and oxidative stress in patients with metabolic syndrome. Biol Trace Elem Res 2013; 151(1):1-8
2013 Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, González-Billault C, Núñez MT. Inflammation alters the expression of DMT1, FPN1 and hepcidin and causes iron accumulation in central nervous system cells. J Neurochem 2013; 126(4):541-549
2013 Ruz M, Carrasco F, Rojas P, Codoceo J, Inostroza J, Basfi-fer K, Valencia A, Vásquez K, Galgani J, Pérez A, López G, Arredondo M, Perez-Bravo F. Zinc as a potential coadjuvant in therapy for type 2 diabetes. Food Nutr Bull 2013; 34(2):215-221
2013 Arredondo M, Mendiburo MJ, Flores S, Singleton ST, Garrick MD. Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells. Biometals 2013 Dec 11
2012 Gaitán DA, Flores S, Pizarro F, Olivares M, Suazo M, Arredondo M. The effect of calcium on non-heme iron uptake, efflux, and transport in intestinal-like epithelial cells (Caco-2 cells). Biol Trace Elem Res 2012; 145(3):300-303
2012 Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Iron, copper, and zinc transport: Inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res 2012; 146(2):281-286
2012 Araya M, Andrews M, Pizarro F, Arredondo M. Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults. Biometals 2012; 25(2):383-391
2012 Villarroel P, Le Blanc S, Arredondo M. Interleukin-6 and lipopolysaccharide modulate hepcidin mRNA expression by hepg2 cells. Biol Trace Elem Res 2012; 150(1-3):496-501
2012 Valencia E, Codner E, Salas-Pérez F, Pizarro C, Carrasco PE, Arredondo M, Pérez-Bravo F. High glucose concentration in T1D patients modulates apoptotic protein expression: Down regulation of bax and fas and up regulation of xiap. Hum Immunol 2012; 73(8):801-804
2012 Le Blanc S, Garrick MD, Arredondo M. Heme Carrier Protein 1 (HCP1) transports heme and is involved in heme-Fe metabolism. Am J Physiol Cell Physiol 2012 ; 302(12):C1780-1785
2012 Le Blanc S, Villarroel P, Candia V, Gavilán N, Soto N, Pérez-Bravo F, Arredondo M. Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity. Biometals 2012; 25(4):725-735
2012 Andrews M, Arredondo M. Hepatic and adipocyte cells respond differentially to iron overload, hypoxic and inflammatory challenge. Biometals 2012; 25(4):749-759
2012 Andrews M, Arredondo M. Ferritin levels and hepcidin mRNA expression in peripheral mononuclear cells from anemic type 2 diabetic patients. Biol Trace Elem Res 2012; 149(1):1-4
2012 Araya M, Núñez H, Pavez L, Arredondo M, Méndez M, Cisternas F, Pizarro F, Sierralta W, Uauy R, González M. Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr 2012; 142(2):233-237
2011 Gaitán D, Flores S, Saavedra P, Miranda C, Olivares M, Arredondo M, López de Romaña D, Lönnerdal B, Pizarro F. Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women. J Nutr 2011; 141(9):1652-1656
2011 Mendiburo MJ, Le Blanc S, Espinoza A, Pizarro F, Arredondo M. Transepithelial heme-iron transport: effect of heme oxygenase overexpression. Eur J Nutr 2011; 50(5):363-371
2011 Arredondo M, Fuentes M, Jorquera D, Candia V, Carrasco E, Leiva E, Mujica V, Hertrampf E, Pérez Bravo F. Cross-talk between body iron stores and diabetes: Iron stores are associated with activity and microsatellite polymorphism of the heme oxygenase and type 2 diabetes. Biol Trace Elem Res 2011; 143(2):625-636
2011 Villarroel P, Flores S, Pizarro F, de Romaña DL, Arredondo M. Effect of dietary protein on heme iron uptake by Caco-2 cells. Eur J Nutr. 2011; 50(8):637-643
2011 Arredondo M, Espinoza A, Pizarro F, Araya M. Searching for specific responses to copper exposure: An in vitro copper challenge in peripheral mononuclear cells. Biol Trace Elem Res 2011; 142(3):407-414
2011 Leiva E, Mujica V, Brito K, Palomo I, Orrego R, Moore-Carrasco R, Vásquez M, Guzmán L, Nuñez S, Díaz N, Icaza G, Arredondo M. High levels of hsCRP are associated with carbohydrate metabolism disorder. J Clin Lab Anal 2011; 25(6):375-381
2010 Arredondo M, Núñez H, López G, Pizarro F, Ayala M, Araya M. Influence of estrogens on copper indicators: In vivo and in vitro studies. Biol Trace Elem Res 2010; 134:252-264
2009 Barbeito AG, Garringer HJ, Baraibar MA, Gao X, Arredondo M, Núñez MT, Smith MA, Ghetti B, Vidal R. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. J Neurochem 2009; 109(4):1067-1078
2008 Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci USA 2008; 105(47):18578-18583
2008 Mujica V, Leiva E, Icaza G, Diaz N, Arredondo M,; Moore R, Orrego R, Vásquez M, Palomo I. Evaluation of metabolic syndrome in adults of Talca City, Chile. Nutr J 2008; 7:14 (20 p.)
2008 Arredondo M, Kloosterman J, Núñez S, Segovia F, Candia V, Flores S, Le Blanc S, Olivares M, Pizarro F. Heme Iron Uptake by Caco-2 Cells is a Saturable, Temperature Sensitive and Modulated by Extracellular pH and Potassium. Biol Trace Elem Res 2008; 125(2):109-119
2008 Suazo M, Olivares F, Mendez MA, Pulgar R, Prohaska JR, Arredondo M, Pizarro F, Olivares M, Araya M, Gonzalez M. CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration. J Nutr Biochem 2008; 19(4):269-274
2008 Arredondo M, Gonzalez M, Olivares M, Pizarro F, Araya M. Ceruloplasmin, an indicator of copper status. Biol Trace Elem Res 2008; 123(1-3):261-269
2008 Núñez H, Araya M, Cisternas F, Arredondo M, Mendez M, Pizarro F, Ortiz A, Ortiz R, Olivares M. Blood biochemical indicators in young and adult Cebus apella of both sexes. J Med Primatol 2008;37(1):12-17
2008 Ayala M, Pizarro F, Mendez MA, Arredondo M, Araya M. Copper and liver function indicators vary depending on the female hormonal cycle and serum hormone binding globulin (SHBG) concentration in healthy women. Biol Trace Elem Res 2008; 121(1):9-15
2007 Leiva E, Mujica V, Elematore I, Orrego R, Díaz G, Prieto M, Arredondo M. Relationship between Apolipoprotein E polymorphism and nephropathy in type-2 diabetic patients. Diabetes Res Clin Pract 2007; 78(2):196-201
2007 Arredondo M, Jorquera D, Carrasco E, Albala C, Hertrampf E. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. Am J Clin Nutr 2007; 86(5):1347-1353
2006 Arredondo M, Tapia V, Rojas A, Aguirre P, Reyes F, Marzolo MP, Nuñez MT. Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells. Biometals 2006; 19(4):379-388
2006 Arredondo M, Salvat V, Pizarro F, Olivares M. Smaller iron particle size improves bioavailability of hydrogen-reduced iron fortified bread. Nutr Res 2006; 26:235-239
2005 Leiva E, Mujica V, Orrego R, Prieto M, Arredondo M. Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile. Diabetes Res Clin Pract 2005; 68(3):244-249
2005 Aguirre P, Mena N, Tapia V, Arredondo M, Nuñez MT. Iron homeostasis in neuronal cells: a role for IREG1. BMC Neurosci 2005; 6(1):3
2005 Arredondo M, Nuñez MT. Iron and copper metabolism. Mol Aspects Med 2005; 26(4-5):313-327
2005 Cisternas F, Tapia G, Arredondo M, Cartier-Ugarte D, Romanque P, Sierralta W, Vial M, Videla L, Araya M. Early histological and functional effects of chronic copper exposure in rat liver. Biometals 2005; 18(5):541-551
2005 Muñoz C, Lopez M, Olivares M, Pizarro F, Arredondo M, Araya M. Differential response of interleukin-2 production to chronic copper supplementation in healthy humans. Eur Cytokine Netw 2005; 16(4):261-265
2005 Araya M, Kelleher SL, Arredondo M, Sierralta W, Vial MT, Uauy R, Lonnerdal B. Effects of chronic copper exposure during early life in rhesus monkeys. Am J Clin Nutr 2005; 81(5):1065-1071
2004 Mazariegos DI, Pizarro F, Olivares M, Nuñez MT, Arredondo M. The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe ascorbate in caco-2 cells are similar. J Nutr 2004; 134:395-398
2004 Arredondo M, Cambiazo V, Tapia L, Nuñez MT, Uauy R, Gonzalez M. Copper overload affects copper an iron metabolism in HepG2 cells. Am J Physiol Gastrointest Liver Physiol 2004; 287(1):G27-32
2003 Pizarro F, Olivares M, Hertrampf E, Arredondo M. Reply to O. Pineda: Iron bis-glycine chelate competes for the nonheme-iron absorption pathway. Am J Clin Nutr 2003; 78:493-497 (Letter)
2003 Arredondo M, Muñoz P, Mura C, Nuñez MT. DMT1, a physiologically relevant apical Cu+1 transporter of intestinal cells. Am J Physiol Cell Physiol 2003; 284:C1525-C1530
2003 Nuñez MT, Nuñez C, Tapia V, Muñoz P, Mazariegos D, Arredondo M, Mura C, Maccioni R. Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1. Biometals 2003; 16:83-90
2003 Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M. Heme-iron absorption is saturable by heme-iron dose in women. J Nutr 2003; 133:2214-2217
2002 Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M, Letelier A, Gidi V. Iron bis-glycine chelate competes for the nonheme-iron absorption pathway. Am J Clin Nutr 2002; 76(3):577-581
2001 Arredondo M, Muñoz P, Mura C, Nuñez M. HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells. FASEB J 2001; 15(7):1276-1278
2000 Arredondo M, Uauy R, Gonzalez M. Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure. Biochim Biophys Acta 2000; 1474:169-176
1999 Olivares M, Pizarro F, Walter T, Arredondo M, Hertrampf E. Bioavailability of iron supplements consumed daily is not different from that of iron supplements consumed weekly. Nutr Res 1999; 19(2):179-190
1997 Arredondo M, Orellana A, Garate M, Nuñez MT. Intracellular iron regulates iron absorption and IRP activity in intestinal ephitelial (Caco-2) cells. Am J Physiol 1997; 273:G275-G280
1996 Tapia V, Arredondo M, Nuñez MT. The regulation of iron absorption by cultured instestinal epithelia (Caco-2) cell monolayers with varied Fe status. Am J Physiol 1996; 271:G443-G447
1996 Nuñez MT, Tapia V, Arredondo M. Intestinal epithelia cell (Caco-2) acquire iron through the basolateral endocytosis of transferrin. J Nutr 1996; 126(9):2151-2158
1993 Walter T, Dallman PR, Pizarro F, Veloso L, Peña G, Bartholomey S, Hertrampf E, Olivares M, Letelier A, Arredondo M. Effectiveness of iron-fortified infant cereal in prevention of iron deficiency anemia. Pediatrics 1993; 91:976-982
2013 Villarroel P, Arredondo M, Olivares M. Anemia de las enfermedades crónicas asociada a obesidad: Papel de la hepcidina como mediador central (Hepcidin as a central mediator of anemia of chronic diseases associated with obesity). Rev Méd Chil 2013; 141(7):887-894
2012 Angel B, Codner E, Arredondo M, Salas F, Pizarro C, Pérez Bravo F. Expresión disminuida de caspasa 3 asociada al polimorfismo del gen del antígeno-4 asociado a linfocito T-citotóxico (CTLA4) en pacientes chilenos con diabetes tipo 1 (Decreased caspase 3 expression and cytotoxic T lymphocyte antigen-4 polymorphism in Chilean patients with type 1 diabetes). Rev Med Chil 2012; 140(9):1109-1115
2012 Andrews M, Soto N, Arredondo M. Efecto de metformina sobre la expresión del factor de necrosis tumoral-α, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2 (Effect of metformin on the expression of tumor necrosis factor-α, Toll like receptors 2/4 and C reactive protein in obese type-2 diabetic patients). Rev Méd Chil 2012: 140(11):1377-1382
2008 Valenzuela C, Letelier A, Olivares M, Arredondo M, Pizarro F. Determinación de hierro, zinc y cobre en carne de bovino (Iron, zinc and copper content of cow meat). Rev Chil Nutr 2008; 35(2):139-146
2006 Gaitan D, Olivares M, Arredondo M, Pizarro F. Biodisponibilidad de hierro en humanos (Iron bioavailability in humans). Rev Chil Nutr 2006; 33(2):142-148
2006 Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M. Understanding copper homeostasis in humans and copper effects on health. Biol Res 2006;39(1):183-187
2006 Mendiburo MJ, Flores S, Pizarro F, Arredondo M. Heme oxygenase 1 overexpression increases iron fluxes in caco-2 cells. Biol Res 2006;39(1):195-197
2006 Aguirre P, Mena N, Tapia V, Rojas A, Arredondo M, Nuñez MT. Antioxidant responses of cortex neurons to iron loading. Biol Res 2006;39(1):103-104
2006 Arredondo M, Martinez R, Nuñez MT, Ruz M, Olivares M. Inhibition of iron and copper uptake by iron, copper and zinc. Biol Res 2006; 39(1):95-102
2000 Olivares M, Pizarro F, Hertrampf E, Walter T, Arredondo M, Letelier A. Fortificación de alimentos con hierro en Chile (Iron fortification of foods in Chile). Rev Chil Nutr 2000; 27:340-344
2000 Nuñez M, Garate M, Arredondo M, Tapia V, Muñoz P. The cellular mechanisms of body iron homeostasis. Biol Res 2000; 33:133-142
1992 Arredondo M, Pizarro F, Walter T, Hertrampf E. Determinación de ferritina sérica por ELISA (Serum ferritin assay by ELISA). Rev Chil Nutr 1992; 20:43-50
1990 Arredondo M, Herrera G, Silva G, Muñoz M, Ziede J, Alfaro L. Lípidos séricos en hipertensos y/o diabéticos de la ciudad de Antofagasta (Lipids in hypertension patients and/or diabetics from Antofagasta city). Rev Chil Tecnol Med 1990; 13(2):650-654
1988 Arredondo M, Pizarro F, Walter T, Hertrampf E. Determinación cuantitativa de hemoglobina fecal por fluorometría (Quantitative determination of fecal hemoglobin for fluorometrics). Rev Chil Tecnol Med 1988; 11:549-554
1985 Silva G, Acuña O, Arredondo M, Vega R, Muñoz M. Efecto crónico de Li en la presión arterial de rata (Lithium chronic effect in rat arterial pressure). Rev Chil Tecnol Med 1985; 8(1):319-324
1984 Arredondo M, Alfaro L, Silva G, Mamani T. Determinación de calicreína urinaria (C.U.) por método indirecto en mamíferos (Urinary kallikrein determination by indirect method in mammals). Rev Chil Tecnol Med 1984; 7(1-2):249-255
2010 Olivares M, Arredondo M, Pizarro F. Hierro (Iron). En: Gil A., editor. Tratado de nutrición. 2ª ed. Madrid: Editorial Médica Panamericana; 2010. v. 1, p. 668-686
2005 Olivares M, Castillo Duran C, Arredondo M, Uauy R. Cobre y zinc en nutrición humana (Copper and zinc in human nutrition). En: Gil A., editor. Tratado de nutrición. Madrid: Acción Médica; 2005. vol.1, p.973-996
2005 Palomo I, Olivares M, Arredondo M, Pizarro F. Alteraciones del metabolismo del hierro y de la síntesis del Hem (Alterations of iron metabolism and hem synthesis). En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p. 133-159
2005 Palomo I, Pizarro F, Olivares M, Arredondo M, Alarcón M, Pombo G. Estudio de laboratorio de anemias nutricionales (Laboratory study of nutritional anemias).En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p.691-700
1990 Walter T, Hertrampf E, Arredondo M, Vega V. Gastrointestinal iron losses in infancy: effect of the diet. In: Hercberg S, Galan P, DupinH., editors. Recent knowledge on iron and folate deficiencies in the world. Paris: INSERM; 1990. p. 283-290 (Colloque INSERM; v.197)
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