Gonzalez Canales Mauricio Alejandro

Director Unidad Académica Nutrición Básica
Profesor Titular
Unidad Académica: 
(56) 229781440
Grado Académico: 
Doctor en Cs. Biologicas Mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Áreas de Interés: 
Mecanismos de regulación de la transcripción
Metabolismo celular de Cobre, Firerro y Zinc


2017 Pastenes L, Valdivieso C, Di Genova A, Travisany D, Hart A, Montecino M, Orellana A, Gonzalez M, Gutiérrez RA, Allende ML, Maass A, Méndez MA. Global gene expression analysis provides insight into local adaptation to geothermal streams in tadpoles of the Andean toad Rhinella spinulosa. Sci Rep. 2017 May 16; 7(1):1966
2016 Almeida AM, Urra C, Moraga C, Jego M, Flores A, Meisel L, González M, Infante R, Defilippi BG, Campos-Vargas R, Orellana A. Proteomic analysis of a segregant population reveals candidate proteins linked to mealiness in peach. J Proteomics 2016; 131:71-81
2016 Latorre M, Ehrenfeld N, Cortés MP, Travisany D, Budinich M, Aravena A, González M, Bobadilla-Fazzini RA, Parada P, Maass A. Global transcriptional responses of Acidithiobacillus ferrooxidans Wenelen under different sulfide minerals. Bioresour Technol 2016; 200:29-34
2016 Bordron P, Latorre M, Cortés MP, González M, Thiele S, Siegel A, Maass A, Eveillard D. Putative bacterial interactions from metagenomic knowledge with an integrative systems ecology approach. Microbiologyopen 2016; 5(1):106-117
2016 Cordero N, Maza F, Navea-Perez H, Aravena A, Marquez-Fontt B, Navarrete P, Figueroa G, González M, Latorre M, Reyes-Jara A. Different tanscriptional responses from slow and fast growth rate strains of Listeria monocytogenes adapted to low temperature. Front Microbiol 2016 Mar 1; 7:229
2016 Mandakovic D, Glasner B, Maldonado J, Aravena P, González M, Cambiazo V, Pulgar R. Genomic-based restriction enzyme selection for specific detection of Piscirickettsia salmonis by 16S rDNA PCR-RFLP. Front Microbiol 2016 May 9; 7:643
2016 Dominguez C, Zuñiga A, Hanna P, Hodar C, Gonzalez M, Cambiazo V. Target genes of Dpp/BMP signaling pathway revealed by transcriptome profiling in the early D.melanogaster embryo. Gene. 2016; 591(1):191-200
2016 Latorre M, Cortés MP, Travisany D, Di Genova A, Budinich M, Reyes-Jara A, Hödar C, González M, Parada P,Bobadilla-Fazzini RA, Cambiazo V, Maass A. The bioleaching potential of a bacterial consortium. Bioresour Technol 2016 Jul 6; 218:659-666
2016 Del Pozo T, Gutiérrez-Garcia R, Latorre M, González M, Suazo M. Identification of reference genes for quantitative real-time PCR studies in human cell lines under copper and zinc exposure. Biometals. 2016; 29(5):935-944
2016 DebRoy S, Saldaña M, Travisany D, Montano A, Galloway-Peña J, Horstmann N, Yao H, González M, Maass A,Latorre M, Shelburne SA. A multi-serotype approach clarifies the catabolite control protein a regulon in the major human pathogen group a streptococcus. Sci Rep. 2016 Sep 1; 6:32442
2016 Acuña M, Castro-Fernández V, Latorre M, Castro J, Schuchman EH, Guixé V, González M, Zanlungo S. Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency. Biochem Biophys Res Commun. 2016 Oct 21;479(3):496-501
2015 Latorre M, Low M, Gárate E, Reyes-Jara A, Murray BE, Cambiazo V, González M. Interplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalis. Metallomics 2015; 7(7):1137-1145
2015 Mandakovic D, Cabrera P, Pulgar R, Maldonado J, Aravena P, Latorre M, Cambiazo V, González M. Complete genome sequence of Microbacterium sp. CGR1, bacterium tolerant to wide abiotic conditions isolated from the Atacama Desert. J Biotechnol 2015; 216:149-150
2015 Pulgar R, Hödar C, Travisany D, Zuñiga A, Domínguez C, Maass A, González M, Cambiazo V. Transcriptional response of Atlantic salmon families to Piscirickettsia salmonis infection highlights the relevance of the iron-deprivation defence system. BMC Genomics 2015;16:495
2015 Quiroz N, Rivas N, Del Pozo T, Burkhead J, Suazo M, González M, Latorre M. Transcriptional activation of glutathione pathways and role of glucose homeostasis during copper imbalance. Biometals 2015; 28(2):321-328
2014 Latorre M, Galloway-Peña J, Roh JH, Budinich M, Reyes-Jara A, Murray BE, Maass A, González M. Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels. Metallomics 2014; 6(3):572-581
2014 Ruiz LM, Jensen EL, Bustos RI, Argüello G, Gutierrez-Garcia R, González M, Hernández C, Paredes R, Simon F, Riedel C, Ferrick D, Elorza AA. Adaptive responses of mitochondria to mild copper deprivation involve changes in morphology, OXPHOS remodeling and bioenergetics. J Cell Physiol 2014; 229(5):607-619
2014 Argüello G, Martinez P, Peña J, Chen O, Platt F, Zanlungo S, González M. Hepatic metabolic response to restricted copper intake in a Niemann-Pick C murine model. Metallomics 2014; 6(8):1527-1539
2014 Travisany D, Cortés MP, Latorre M, Di Genova A, Budinich M, Bobadilla-Fazzini RA, Parada P, González M, Maass A. A new genome of Acidithiobacillus thiooxidans provides insights into adaptation to a bioleaching environment. Res Microbiol 2014 2014; 165(9):743-752
2013 Gutiérrez-García R, Del Pozo T, Suazo M, Cambiazo V, González M. Physiological copper exposure in Jurkat cells induces changes in the expression of genes encoding cholesterol biosynthesis proteins. Biometals 2013; 26(6):1033-1040
2012 Hödar C, Moreno P, di Genova A, Latorre M, Reyes-Jara A, Maass A, González M, Cambiazo V. Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative analysis of ArsR and MerR metal regulators. Biometals 2012; 25(1):75-93
2012 López G, Latorre M, Reyes-Jara A, Cambiazo V, González M. Transcriptomic response of Enterococcus faecalis to iron excess. Biometals 2012; 25(4):737-747
2012 Mera-Adasme R, Mendizábal F, Gonzalez M, Miranda-Rojas S, Olea-Azar C, Sundholm D. Computational studies of the metal-binding site of the wild-type and the H46R mutant of the copper, zinc superoxide dismutase. Inorg Chem 2012; 51(10):5561-5568
2012 Vázquez MC, Martínez P, Alvarez AR, González M, Zanlungo S. Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease. Biometals 2012; 25(4):777-786
2012 Araya M, Núñez H, Pavez L, Arredondo M, Méndez M, Cisternas F, Pizarro F, Sierralta W, Uauy R, González M. Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr 2012; 142(2):233-237
2011 Latorre M, Olivares F, Reyes-Jara A, López G, González M. CutC is induced late during copper exposure and can modify intracellular copper content in Enterococcus faecalis. Biochem Biophys Res Commun 2011; 406(4):633-637
2011 di Genova A, Aravena A, Zapata L, González M, Maass A, Iturra P. SalmonDB: A bioinformatics resource for Salmo salar and Oncorhynchus mykiss. Database (Oxford) 2011 Nov 26; 2011: bar 050
2011 Vázquez MC, del Pozo T, Robledo FA, Carrasco G, Pavez L, Olivares F, González M, Zanlungo S. Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress. Plos One 2011; 6(12):e28777
2010 Del Pozo T, Cambiazo V, González M. Gene expression profiling analysis of copper homeostasis in Arabidopsis thaliana. Biochem Biophys Res Comm 2010; 393(2):248-252
2010 Reyes-Jara A, Latorre M, López G, Bourgogne A, Murray BE, Cambiazo V, González M. Genome-wide transcriptome analysis of the adaptive response of Enterococcus faecalis to copper exposure. Biometals 2010; 23(6):1105-1112
2010 Hödar C, Assar R, Colombres M, Aravena A, Pavez L, González M, Martínez S, Inestrosa NC, Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics 2010 Jun 1; 11:348
2010 Nilo R, Saffie C, Lilley K, Baeza-Yates R, Cambiazo V, Campos-Vargas R, González M, Meisel LA, Retamales J, Silva H, Orellana A. Proteomic analysis of peach fruit mesocarp softening and chilling injury using difference gel electrophoresis(DIGE). BMC Genomics 2010; 11:43.
2009 Zúñiga A, Hödar C, Hanna P, Ibáñez F, Moreno P, Pulgar R, Pastenes L, Gonzalez M, Cambiazo V. Genes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis. BMC Biol 2009 Sep 22;7:61
2009 Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass M, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway. J Cell Physiol 2009; 221:658-667
2009 Vizoso P, Meisel LA, Tittarelli A, Latorre M, Saba J, Caroca R, Maldonado J, Cambiazo V, Campos-Vargas R, Gonzalez M, Orellana A, Silva H. Comparative EST transcript profiling of peach fruits under different post-harvest conditions reveals candidate genes associated with peach fruit quality. BMC Genomics 2009; 10(1):423
2009 Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M. Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochem Biophys Res Commun 2009; 382(4):740-744
2008 Suazo M, Olivares F, Mendez MA, Pulgar R, Prohaska JR, Arredondo M, Pizarro F, Olivares M, Araya M, Gonzalez M. CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration. J Nutr Biochem 2008; 19(4):269-274
2008 González-Agüero M, Pavez L, Ibáñez F, Pacheco I, Campos-Vargas R, Meisel LA, Orellana A, Retamales J, Silva H, Gonzalez M, Cambiazo V. Identification of woolliness response genes in peach fruit after post-harvest treatments. J Exp Bot 2008; 59(8):1973-1986
2008 Arredondo M, Gonzalez M, Olivares M, Pizarro F, Araya M. Ceruloplasmin, an indicator of copper status. Biol Trace Elem Res 2008; 123(1-3):261-269
2008 Gonzalez M, Reyes A, Suazo M, Jo WJ, Vulpe C. Expression of copper-related genes in response to copper load. Am J Clin Nutr 2008; 88:830S-834S
2006 Latorre M, Silva H, Saba J, Guziolowski C, Vizoso P, Martinez V, Maldonado J, Morales A, Caroca R, Cambiazo V, Campos-Vargas R, Gonzalez M, Orellana A, Retamales J, Meisel LA. JUICE: a data management system that facilitates the analysis of large volumes of information in an EST project workflow. BMC Bioinformatics 2006; 23(7):513 (11 p.)
2006 Aracena J, Gonzalez M, Zuniga A, Mendez MA, Cambiazo V. Regulatory network for cell shape changes during Drosophila ventral furrow formation. J Theor Biol 2006; 239(1):49-62
2006 Campos-Vargas R, Becerra O, Baeza-Yates R, Cambiazo V, González M, Meisel L, Orellana A, Retamales J, Silva H, Defilippi B. Seasonal variation in the development of chilling injury in ‘O’Henry’ peaches. Scientia Horticulturae 2006; 110:79-83
2005 Araya M, Olivares M, Pizarro F, Mendez MA, Gonzalez M, Uauy R. Supplementing copper at the upper level of the adult dietary recommended intake induces detectable but transient changes in healthy adults. J Nutr 2005; 135:2367-2371
2005 Meisel L, Fonseca B, Gonzalez S, Baeza-Yates R, Cambiazo V, Campos R, Gonzalez M, Orellana A, Retamales J, Silva H. A rapid and efficient method for purifying high quality total RNA from peaches (Prunus persica) for functional genomics analyses. Biol Res 2005; 38(1):83-88
2004 Mendez MA, Araya M, Olivares M, Pizarro F, Gonzalez M. Sex and ceruloplasmin modulate the response to copper exposure in healthy individuals. Environ Health Perspect 2004; 112(17):1654-1657
2004 Arredondo M, Cambiazo V, Tapia L, Nuñez MT, Uauy R, Gonzalez M. Copper overload affects copper an iron metabolism in HepG2 cells. Am J Physiol Gastrointest Liver Physiol 2004; 287(1):G27-32
2004 Tapia L, Gonzalez Aguero M, Cisternas MF, Suazo M, Cambiazo V, Uauy R, Gonzalez M. Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and supra-physiological exposure levels. Biochem J 2004; 378(Pt 2):617-624
2004 Rodriguez JP, Gonzalez M, Rios S, Cambiazo V. Cytoskeletal organization of human mesenchymal stem cells (MSC) changes during their osteogenic differentiation. J Cell Biochem 2004; 93(4):721-731
2003 Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R. Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure. Am J Clin Nutr 2003; 77:646-650
2003 Tapia L, Suazo M, Hödar C, Cambiazo V, Gonzalez M. Copper exposure modifies the content and distribution of trace metals in mammalian cultured cells. Biometals 2003; 16(1):169-174
2003 Araya M, Olivares M, Pizarro F, Gonzalez M, Speisky H, Uauy R. Copper exposure and potential biomarkers of copper metabolism. Biometals 2003; 16(1):199-204
2002 Mendez MA, Hodar C, Vulpe C, Gonzalez M, Cambiazo V. Discriminant analysis to evaluate clustering of gene expression data. Febs Lett 2002; 522(1-3):24-28
2002 Rodriguez JP, Rios S, Gonzalez M. Modulation of the proliferation and differentiation of human mesenchymal stem cells by copper. J Cell Biochem 2002; 85(1):92-100
2001 Cambiazo V, Gonzalez M, Maccioni RB. Expression pattern of DMAP-85 during Drosophila embryonic development. Mech Dev 2001; 108:197-201
2000 Arredondo M, Uauy R, Gonzalez M. Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure. Biochim Biophys Acta 2000; 1474:169-176
1999 Cambiazo V, Gonzalez M, Isamit C, Maccioni RB. The beta-isoform of heat shock protein Hsp-90 is structurally related with human microtubule-interacting protein Mip-90. FEBS Lett 1999; 457:343-347
1999 Ruiz FH, Gonzalez M, Bodini M, Opazo C, Inestrosa NC. Cysteine 144 is a key residue in the copper reduction by the Amyloid-?- precursor protein. J Neurochem 1999; 73:1288-1292
1998 Gonzalez M, Cambiazo V, Maccioni RB. The interaction of Mip-90 with microtubules and microfilaments in human fibroblasts. Exp Cell Res 1998; 239:243-253
1998 Uauy R, Olivares M, Gonzalez M. Essentiality of copper in humans. Am J Clin Nutr 1998; 67(5 Suppl):952S-959S
1996 Gonzalez M, García C, Nieto A. Regional differences in uteroglobin biosynthesis along the rabbit oviduct: Inmuno-histochemical and biochemical studies. Histochem J 1996; 28:209-215
1995 Cambiazo V, Gonzalez M, Maccioni RB. DMAP-85: a Tau-like protein from Drosophila melanogaster larvae. J Neurochem 1995; 64:1288-1297
1995 Gonzalez M, Cambiazo V, Maccioni RB. Identification of a new microtubule-interacting protein Mip-90. Eur J Cell Biol 1995; 67:158-169
1995 Vial C, Armas Portela R, Avila J, Gonzalez M, Maccioni RB. A 205 kDa protein from non-neuronal cells in culture contains tubulin binding epitopes. Mol Cell Biochem 1995; 144:109-116
2006 Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M. Understanding copper homeostasis in humans and copper effects on health. Biol Res 2006;39(1):183-187
2006 Armendariz AD, Olivares F, Pulgar R, Loguinov A, Cambiazo V, Vulpe CD, Gonzalez M. Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines. Biol Res 2006;39(1):125-142
2006 Reyes A, Leiva A, Cambiazo V, Mendez MA, Gonzalez M. Cop-like operon: structure and organization in species of the Lactobacillale order. Biol Res 2006; 39(1):87-93
2005 Meisel L, Fonseca B, Gonzalez S, Baeza-Yates R, Cambiazo V, Campos R, Gonzalez M, Orellana A, Retamales J, Silva H. A rapid and efficient method for purifying high quality total RNA from peaches (Prunus persica) for functional genomics analyses. Biol Res 2005; 38(1):83-88
2003 Uauy R, Gonzalez M, Olivares M, Araya M. Copper and human health: Effects of deficit and excess. In: Lagos GE, Warner AEM, Sánchez M., editors. Copper 2003. Montreal: Canadian Institute of Mining, Metallurgy and Petroleum; 2003. v.1, p.7-31
2003 Araya M, Olivares M, Gonzalez M, Pizarro F, Uauy R. Copper biomarkers for human health. In: Lagos GE, Warner AEM, Sánchez M., editors. Copper 2003. Montreal: Canadian Institute of Mining, Metallurgy and Petroleum; 2003. v.2, p.441-446
2002 Araya M, Gonzalez M, Olivares M, Uauy R. Biological effects of chronic copper exposure. In: Massaro E., editor. Handbook of copper pharmacology and toxicology. Totowa, NJ: Humana Press, Inc.; 2002. p.385-396
1999 Olivares M, Uauy R, Icaza G, Gonzalez M. Models to evaluate health risks derived from copper exposure /Intake in humans. In: Leone A, Mercer J, editors. Copper transport and its disorders. New York: Kluwer Academic / Plenum Publisher; 1999. p. 17-28 (Advances in Experimental Medicine and Biology; v.448)
1997 Olivares M, Gonzalez M, Icaza G, Uauy R. Mechanism of adaptation to copper deficit and excess in humans: basis to assess health risk. In: Lagos GE, Badilla Ohlbaum R., editors. Advances in risk assessment of copper in the environment. Santiago: Universidad Católica de Chile /Centro de Investigación Minera Metalúrgica; 1997. p. 291-326
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