Cargo: Profesor Titular
Ver perfil Uchile

Licenciado en Bioquímica, Universidad de Concepción; Bioquímico Universidad e Chile. Beca de investigación nivel Postdoctorado. Reproductive Endocrinology Program, Departments of Obstetrics and Gynecology Programs  and Biologycal Chemistry. University of Michigan.

Grado Académico
  • Licenciado Bioquímica, Universidad de Concepción
Unidad Académica

Nutrición Humana

Áreas de interés
  • Endocrinología de Esteroides
  • Menopausia
  • Soja
1988 Monckeberg F, Agosin E, Perretta M, Rosemblatt M, Spencer E, Valenzuela A, Valladares L. La revolución de la bioingeniería (The revolution of bioengineering). Santiago: Publicaciones Técnicas Mediterráneo; 1988
2008 Sierralta WD, Epuñán MJ, Reyes JM, Valladares LE, Pino AM. A synthetic peptide derived from alpha-fetoprotein inhibits the estradiol-induced proliferation of mammary tumor cells in culture through the modulation of p21. In: Li JJ, Li SA, Mohla S, Rochefort H, Maudelonde T., editors. Hormonal carcinogenesis V: Proceedings of the Fifth International Symposium on Hormonal Carcinogenesis. New York: Springer Science + Buseness Media LLC; 2008. p.463-468 (Adv Exp Med Biol; 617)
2017 Plaza-Parrochia F, Oróstica L, García P, Vera C, Romero C, Valladares L, Vega M. Molecular mechanisms of androstenediol in the regulation of the proliferative process of human endometrial cells. Reprod Sci. 2017; 24(7):1079-1087
2017 Opazo R, Valladares L, Romero J. Comparison of gene expression patterns of key growth genes between different rate growths in zebrafish (Danio rerio) siblings. Lat Am J Aquat Res. 2017; 45(4):766-775
2017 Plaza-Parrochia F, Romero C, Valladares L, Vega M. Endometrium and steroids, a pathologic overview. Steroids. 2017 Oct;126:85-91
2015 Sáez-Briones P, Soto-Moyano R, Burgos H, Castillo A, Valladares L, Morgan C, Pérez H, Barra R, Constandil L, Laurido C, Hernández A. β2-adrenoceptor stimulation restores frontal cortex plasticity and improves visuospatial performance in hidden-prenatally-malnourished young-adult rats. Neurobiol Learn Mem 2015; 119:1-9
2015 Plaza-Parrochia F, Poblete C, Gabler F, Carvajal R, Romero C, Valladares L, Vega M. Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome. Steroids 2015; 104:189-195
2014 Plaza-Parrochia F, Bacallao K, Poblete C, Gabler F, Carvajal R, Romero C, Valladares L, Vega M. The role of androst-5-ene-3β,17β-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ovary syndrome. Steroids 2014; 89:11-19
2012 Barra R, Soto-Moyano R, Valladares L, Morgan C, Pérez H, Burgos H, Olivares R, Sáez-Briones P, Laurido C, Hernández A. Knockdown of α(2C)-adrenoceptors in the occipital cortex rescued long-term potentiation in hidden prenatally malnourished rats. Neurobiol Learn Mem 2012; 98(3):228-234
2012 Cruz P, Epuñán MJ, Ramírez ME, Torres CG, Valladares LE, Sierralta WD. 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. Oncol Rep 2012; 28(3):992-998
2012 Garrido A, Muñoz Y, Sierralta W, Valladares L. Metabolism of dehydroepiandrosterone sulfate and estrone-sulfate by human platelets. Physiol Res 2012; 61(4):381-388
2012 Muñoz YC, Gomez GI, Moreno M, Solis CL, Valladares LE, Velarde V. Dehydroepiandrosterone Prevents the Aggregation of Platelets Obtained from Postmenopausal Women with Type 2 Diabetes Mellitus through the Activation of the PKC/eNOS/NO Pathway. Horm Metab Res 2012; 44(8):625-631
2011 Flores O, Pérez H, Valladares L, Morgan C, Gatica A, Burgos H, Olivares R, Hernández A. Hidden prenatal malnutrition in the rat: role of β(1) -adrenoceptors on synaptic plasticity in the frontal cortex. J Neurochem 2011; 119(2):314-323
2011 Torres CG, Ramírez ME, Cruz P, Epuñan MJ, Valladares LE, Sierralta WD. 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncol Rep 2011; 26(2):389-397
2010 Perez H, Soto-Moyano R, Ruiz S, Hernandez A, Sierralta W, Olivares R, Núñez H, Flores O, Morgan C, Valladares L, Gatica A, Flores FJ. A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. Neurosci Lett 2010; 483(1):41-46
2010 Flores O, Núñez H, Perez H, Morgan C, Soto-Moyano R, Valladares L, Burgos H, Olivares R, Hernandez A. beta-Adrenoceptor blockade depresses molecular and functional plasticities in the rat neocortex. Brain Res Bull 2010; 82(5-6):284-288
2010 Plaza F, Gabler F, Romero C, Vantman D, Valladares L, Vega M. The conversion of dehydroepiandrosterone into androst-5-ene-3beta,17beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome. Steroids 2010; 75(12):810-817
2010 Cruz P, Torres C, Ramírez ME, Epuñán MJ, Valladares LE, Sierralta W. Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol. Exp Ther Med 2010; 1(3):531-536
2009 Muñoz Y, Garrido A, Valladares L. Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets. Thromb Res 2009; 123(5):740-744
2008 Guerrero-Bosagna CM, Sabat P, Valdovinos FS, Valladares LE, Clark SJ. Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice. BMC Physiol 2008; 8(1):17 (32 p.)
2008 Núñez H, Ruiz S, Soto Moyano R, Navarrete M, Valladares L, White A, Perez H. Fetal undernutrition induces overexpression of CRH mRNA and CRH protein in hypothalamus and increases CRH and corticosterone in plasma during postnatal life in the rat. Neurosci Lett 2008; 448(1):115-119
2008 Hernandez A, Burgos H, Mondaca M, Barra R, Núñez H, Perez H, Soto Moyano R, Sierralta W, Fernández V, Olivares R, Valladares L. Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization. Neural Plast 2008; 2008:ID 646919 (9 p.)
2008 Bacallao K, Leon L, Gabler F, Soto E, Romero C, Valladares L, Vega M. In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia. J Steroid Biochem Mol Biol 2008; 110(1-2):163-169
2008 Leon L, Bacallao K, Gabler F, Romero C, Valladares L, Vega M. Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome. Steroids 2008; 73(1):88-95
2008 Torres C, Antileo E, Epuñán MJ, Pino AM, Valladares LE, Sierralta WD. A cyclic peptide derived from alpha-fetoprotein inhibits the proliferative effects of the epidermal growth factor and estradiol in MCF7 cells. Oncol Rep 2008; 19(6):1597-1603
2008 Sierralta WD, Epuñán MJ, Reyes JM, Valladares L, Pino AM. A synthetic peptide derived from alpha-fetoprotein inhibits the estradiol-induced proliferation of mammary tumor cells in culture through the modulation of p21. Adv Exp Med Biol 2008; 617:463-468
2008 Sierralta WD, Epuñan MJ, Reyes JM, Valladares LE, Andersen TT, Bennett JA, Jacobson HI, Pino AM. A peptide derived from alpha-fetoprotein inhibits the proliferation induced by estradiol in mammary tumor cells in culture. Oncol Rep 2008;19(1):229-235
2007 Navarrete M, Nunez H, Ruiz S, Soto Moyano R, Valladares L, White A, Perez H. Prenatal undernutrition decreases the sensitivity of the hypothalamo-pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challenges. Neurosci Lett 2007; 419:99-103
2006 Garrido A, De la Maza MP, Hirsch S, Valladares L. Soy isoflavones affect platelet thromboxane A2 receptor density but not plasma lipid in menopausal women. Maturitas 2006; 54:270-276
2006 Sierralta W, Hernandez A, Valladares L, Perez H, Mondaca M, Soto-Moyano R. Mild prenatal protein malnutrition increases alpha(2C)-adrenoceptor expression in the rat cerebral cortex during postnatal life. Brain Res Bull 2006; 69(5):580-586
2006 Soto Moyano R, Burgos H, Flores F, Valladares L, Sierralta W, Fernandez V, Perez H, Hernandez P, Hernandez A. Melatonin administration impairs visuo-spatial performance and inhibits neocortical long-term potentiation in rats. Pharmacol Biochem Behav 2006; 85:408-414
2005 Soto Moyano R, Valladares L, Sierralta W, Perez H, Mondaca M, Fernandez V, Burgos H, Hernandez A. Mild prenatal protein malnutrition increases alpha2C-adrenoceptor density in the cerebral cortex during postnatal life and impairs neocortical long-term potentiation and visuo-spatial performance in rats. J Neurochem 2005; 93(5):1099-109
2005 Guerrero-Bosagna C, Sabat P, Valladares L. Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?. Evol Dev 2005; 7(4):341-350
2004 Mondaca M, Hernandez A, Perez H, Valladares L, Sierralta W, Fernandez V, Soto Moyano R. Alpha(2)-Adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex. Brain Res 2004; 1021(2):292-296
2004 Mondaca M, Hernandez A, Valladares L, Sierralta W, Noseda R, Soto Moyano R. Involvement of melatonin metabolites in the long-term inhibitory effect of the hormone on rat spinal nociceptive transmnission. Pharmacol Biochem Behav 2004; 77(2):275-279
2004 Noseda R, Hernandez A, Valladares L, Mondaca M, Laurido c, Soto Moyano R. Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT(2) receptor-dependent. Neurosci Lett 2004; 360(1-2):41-44
2003 Torres Farfan C, Richter HG, Rojas Garcia P, Vergara M, Forcelledo ML, Valladares L, Torrealba F, Valenzuela GJ, Seron-Ferre M. mt1 melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by melatonin. J Clin Endocrinol Metab 2003; 88(1):450-458
2002 Laurido C, Pelissier T, Soto Moyano R, Valladares L, Flores F, Hernandez A. Effect of melatonin on at spinal cord nociceptive transmission. Neuroreport 2002; 13:89-91
2000 Pino AM, Valladares L, Palma M, Mancilla A, Yañez M, Albala C. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab 2000; 85:2797-2800
2000 Valladares L, Erices A, Lioi X, Iturriaga H. Characterization of the oligosaccharides of plasma sex hormones binding globulin from noncirrhotic alcoholic patients. Steroids 2000; 65(5):275-280
1999 Iturriaga H, Lioi X, Valladares L. Sex hormone-binding globulin in non-cirrhotic alcoholic patient during early withdrawal and after longer abstinence. Alcohol Alcohol 1999; 34(6):903-909
1998 Estay F, Neira R, Díaz N, Valladares L. Gametogenesis and sex steroid profiles in cultured coho salmon (Oncorhynchus kisutch, Walbaum). J Exp Zool 1998; 280(6):429-438
1997 Vera H, Tijmes M, Valladares L. Melatonin and testicular function: characterization of binding sites for 2- 125 l-lodomelatonin in immature rat testes. Steroids 1997; 62:226-229
1996 Tijmes M, Pedraza R, Valladares L. Melatonin in the rat testis: evidence for local synthesis. Steroids 1996; 61:65-68
1996 Estay FJ, Díaz N, Valladares L. Ovarian morphological changes and plasma sex steroid profiles in two cultured salmon (Oncorhynchus kisutch and Salmo salar) broostock populations. Fish Physiol 1996; 26:46-48
1995 Iturriaga H, Valladares L, Hirsch S, Devoto E, Perez C, Bunout D, Lioi X, Petermann M. Effects of abstinence on sex hormone profile in alcoholic patients without failure. J Endocrinol Invest 1995; 18:638-644
1993 Ronco AM, Llanos M, Valladares L. Human chorionic gonadotropin and free beta molecules stimulate phospholipid methylation in intact rat Leydig cells. Steroids 1993; 58:314-319
1993 Ronco AM, Valladares L. Phospholipid methylation decreases in hCG-induced desensitized rat Leydig cells. J Endocrinol 1993; 138:65-71
1992 Ronco AM, Valladares L, Devoto L, Ahumada A, Pino AM. In vitro effect of hCG on steroidogenesis on the testicular tissue from a patient with complete androgen resistance. J Endocrinol Invest 1992; 15:683-687
1992 Ronco AM, Valladares L. The effect of hCG-induced desensitization on RNA synthesis in rat Leydig cells. Biochem Int 1992; 27:65-74
1992 Pino AM, Inostroza H, Valladares L. Detection of testosterone secretion from individual rat Leydig cells. J Steroid Biochem Mol Biol 1992; 41:167-170
1988 Ronco AM, Pino AM, Valladares L. RNA aynthesis in the Leydig cells of the mature rat: effect of oestradiol-17B. J Endocrinol 1988; 116:387-392
1988 Pino AM, Valladares L. Evidence for a Leydig cell progesterone receptor in the rat. J Steroid Biochem 1988; 29:709-714
1986 Valladares L, Ronco AM, Pino AM. RNA synthesis in Leydig cells during sexual maturation in the rat: effect of LH. J Endocrinol 1986; 110:551-556
1985 Llanos M, Ronco AM, Pino AM, Valladares L. The transmethylations inhibitor 3-deazaadenosine, inhibits in vitro testosterone production by rat testis interstitial cell stimulated with HCG. J Steroid Biochem 1985; 23:73-76
1984 Valladares LE, Ronco AM. Effect of luteinizing hormone on RNA synthesis in Leydig cells of immature rats. J Steroid Biochem. 1984 Oct;21(4):443-6
1973 Minguell J, Sierralta W, Valenzuela A, Romero C, Valladares L, Perretta M. Molecular mechanisms of the erythropoietic process. Acta Physiol Latinoam 1973; 23:541-543
2012 Valladares L, Garrido A, Sierralta W. Isoflavonas de soya y salud humana: Cáncer de mama y sincronización de la pubertad (Soy isoflavones and human health: Breast cancer and puberty timing). Rev Méd Chil 2012; 140(4):512-516
2003 Garrido A, De la Maza MP, Valladares L. Fitoestrógenos dietarios y sus potenciales beneficios en la salud del adulto humano (Potential health benefits of phytoestrogens). Rev Med Chil 2003; 131(11):1321-1328
2001 Ronco AM, Llanos M, Valladares L, Garrido A. Riesgo potencial para la salud humana de los xenobióticos ambientales como moduladores endocrinos (Potential health risks of environmental xenobiotics as endocrine modulators). Rev Chil Nutr 2001; 28(3):406-413
1999 Ronco AM, Llanos M, Valladares L. Anabólicos en producción pecuaria: un riesgo para la salud del consumidor? (Use of anabolics in livestock: a health risk for the consumer?). Rev Chil Nutr 1999; 26:288-294
1999 Ronco AM, Llanos M, Valladares L. Anabólicos en producción pecuaria: un riesgo para la salud del consumidor? (Use of anabolics in livestock: a health risk for the consumer?). Rev Chil Nutr 1999; 26:288-294
1999 Huneeus A, Alba F, Fernandez W, Valladares L. Tumor de Sertoli y Leydig. Caso clínico (Sertoli and Leydig tumor. Clinical case). Rev Med Chil 1999; 127(7):835-838
1995 Garcia H, Youlton R, Valladares L, Jara A, Cattani A, Tijmes M, García C. Telarquia prematura: aumento de la actividad estrogénica total en el plasma (Premature thelarche: evidence of increase serum total estrogenic activity). Rev Chil Pediatr 1995; 66(2):83-88
1995 Jara A, Youlton R, Valladares L, Garcia H, Cattani A, Venegas P, Tijmes M. Telarquia prematura (Premature thelarche). Rev Chil Pediatr 1995; 66(2):89-92
1993 Vera H, Tijmes M, Ronco AM, Valladares L. Melatonin binding sites in interstitial cells from immature rat testes. Biol Res 1993; 26:337-340
1990 Youlton R, Valladares L. Hormonas, alimentos y telarquia precoz (Hormones, foods and premature thelarche). Rev Chil Pediatr 1990; 61(1):51-53
1989 Olivares A, Valladares L, Bustos-Obregon E, Nuñez S. Testicular function of sexually immature rats chronically treated with melatonin. Arch Biol Med Exp 1989; 22(4):387-393
1984 Valladares L. Ronco AM, Pino AM. Acción del estradiol en la regulación de la esteroidogenesis testicular (Action of stradiol on the regulation of testicular steroidogenesis). Rev Med Chil 1984; 112(6):599-603
1976 Perretta M, Valladares L, Romero C, Sierralta W, Valenzuela A, Spencer E, Cañas P, Minguell J. Hormone action on the cell nucleus: effect of erythropoietin and testosterone on bone marrow. Arch Biol Med Exp 1976; 10:35-40

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