Martinez Winkler Jorge

Profesor Titular
Email: 
jmartine@inta.uchile.cl
Teléfono: 
(56) 229781419
(56) 229781433

Publicaciones

2017 Tobar N, Porras O, Smith PC, Barros LF, Martínez J. Modulation of mammary stromal cell lactate dynamics by ambient glucose and epithelial factors. J Cell Physiol 2017; 232(1):136-144
2017 Kallens V, Tobar N, Molina J, Bidegain A, Smith PC, Porras O, Martínez J. Glucose promotes a pro-oxidant and pro-inflammatory stromal microenvironment which favors motile properties in breast tumor cells. J Cell Biochem 2017; 118(5):994-1002
2016 Retamal IN, Hernández R, González-Rivas C, Cáceres M, Arancibia R, Romero A, Martínez C, Tobar N, Martínez J, Smith PC. Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells. J Periodontal Res 2016 Feb 4 (In Press)
2015 Romero A, Cáceres M, Arancibia R, Silva D, Couve E, Martínez C, Martínez J, Smith PC. Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E2 production in human gingival fibroblasts. J Periodontal Res 2015; 50(3):371-379
2015 Smith PC, Martínez C, Cáceres M, Martínez J. Research on growth factors in periodontology. Periodontol 2000; 2015 Feb;67(1):234-250
2014 Tobar N, Avalos MC, Méndez N, Smith PC, Bernabeu C, Quintanilla M, Martínez J. Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells. Carcinogenesis 2014; 35(8):1770-1779
2014 Tobar N, Toyos M, Urra C, Méndez N, Arancibia R, Smith PC, Martínez J. C-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer 2014 Aug 30;14(1):640
2013 Silva D, Arancibia R, Tapia C, Acuña-Rougier C, Diaz-Dosque M, Cáceres M, Martínez J, Smith PC. Chitosan and platelet-derived growth factor synergistically stimulate cell proliferation in gingival fibroblasts. J Periodontal Res 2013; 48(6):677-686
2013 Arancibia R, Oyarzún A, Silva D, Tobar N, Martínez J, Smith PC. Tnf-α inhibits Tgf-β-stimulated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblasts. J Periodontol 2013; 84(5):683-693
2013 Arancibia R, Maturana C, Silva D, Tobar N, Tapia C, Salazar JC, Martínez J, Smith PC. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. J Dent Res 2013; 92(8):740-745
2012 Cáceres M, Martínez C, Martínez J, Smith PC. Effects of platelet-rich and -poor plasma on the reparative response of gingival fibroblasts. Clin Oral Implants Res 2012; 23(9):1104-1111
2012 Silva D, Cáceres M, Arancibia R, Martínez C, Martínez J, Smith PC. Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation. J Periodontal Res 2012; 47(5):599-607
2011 Cáceres M, Romero A, Copaja M, Díaz-Araya G, Martínez J, Smith PC. Simvastatin alters fibroblastic cell responses involved in tissue repair. J Periodontal Res 2011; 46(4):456-463
2010 Tobar N, Guerrero J, Smith PC, Martínez J. NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Br J Cancer 2010; 103(7):1040-1047
2010 Oyarzún A, Arancibia R, Hidalgo R, Peñafiel C, Cáceres M, González MJ, Martínez J, Smith PC. Involvement of MT1-MMP and TIMP-2 in human periodontal disease. Oral Dis 2010; 16(4):388-395
2010 Guerrero J, Tobar N, Cáceres M, Espinoza L, Escobar P, Dotor J, Smith PC, Martínez J. Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-beta1 and TNF-alpha. Breast Cancer Res Treat 2010; 119(2):497-508
2010 Cifuentes M, Mattar P, Fuentes C, Tobar N, Hugo E, Ben-Jonathan N, Rojas C, Martinez J. Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and LS14 human adipose cell line. Arch Biochem Biophys 2010; 500(2):151-156
2009 Smith PC, Guerrero J, Tobar N, Cáceres M, González MJ, Martinez J. TNF-alpha stimulated MT1-MMP production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts. J Periodontal Res 2009; 44:73-80
2009 Arancibia R, Cáceres M, Martínez J, Smith PC. Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts. J Periodontal Res 2009; 44(6):726-735
2008 Cáceres M, Hidalgo R, Sanz A, Riera P, Martinez J, Smith PC. Effect of platelet-rich plasma on cell adhesion, cell migration and myofibroblastic differentiation in human gingival fibroblasts. J Periodontol 2008; 79:714-720
2008 Cáceres M, Tobar N, Guerrero J, Smith PC, Martinez J. c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway. J Cell Biochem 2008; 103(3):986-993
2008 Tobar N, Cáceres M, Santibañez JF, Smith PC, Martinez J. RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism. Cancer Lett 2008; 267:125-132
2006 Smith PC, Martinez J. Differential uPA expression by TGF-beta1 in gingival fibroblasts. J Dent Res 2006; 85(2):150-155
2006 Smith PC, Cáceres M, Martinez J. Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-beta1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways. J Periodontal Res 2006; 41(5):418-425
2006 Cárcamo C, Pardo E, Oyanadel C, Bravo-Zehnder M, Bull P, Cáceres M, Martinez J, Massardo L, Jacobelli S, González A, Soza A. Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells. Exp Cell Res 2006; 312(4):374-386
2005 Caceres M, Guerrero J, Martinez J. Overexpression of RhoA-GTP induces activation of the Epidermal Growth Factor Receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells. Exp Cell Res 2005; 309(1):229-238
2004 Smith PC, Santibañez JF, Morales JP, Martinez J. Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J Periodontal Res 2004; 39(6):380-387
2004 Guerrero J, Santibañez JF, Gonzalez A, Martinez J. EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp Cell Res 2004; 292(1):201-208
2003 Santibañez JF, Olivares D, Guerrero J, Martinez J. Cyclic AMP inhibits TGFbeta 1-induced cell-scattering and invasiveness in murine-transformed keratinocytes. Int J Cancer 2003; 107(5):715-720
2002 Santibañez JF, Guerrero J, Quintanilla M, Fabra A, Martinez J. Transforming growth factor-beta 1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem Biophys Res Commun 2002; 296(2):267-273
2002 Santibañez JF, Quintanilla M, Martinez J. TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells. Febs Lett 2002; 520(1-3):171-176
2001 Juretic N, Santibañez JF, Hurtado C, Martinez J. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line. J Cell Biochem 2001; 83:92-98
2000 Smith PC, Martínez C, Cáceres M, Martínez J. Research on growth factors in periodontology. Periodontol 2000; 2015 Feb;67(1):234-250
2000 Santibañez JF, Iglesias M, Frontelo P,, Martinez J, Quintanilla M. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-b1 in transformed keratinocytes. Biochem Biophys Res Commun 2000; 273:521-527
2000 Santibañez JF, Quintanilla M, Martinez J. Genistein and curcumin block TGF-b1 induced uPA expression and migratory and invasive phenotype in mouse epidermal keratinocytes. Nutr Cancer 2000; 37(1):49-54
2000 Rodriguez JP, Montecinos L, Rios S, Reyes P, Martinez J. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring the adipogenic differentiation. J Cell Biochem 2000; 79:557-565
1999 Martinez J, Fuentes M, Cambiazo V, Santibañez JF. Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cell line. Int J Cancer 1999; 83:278-282
1999 Santibañez JF, Frontelo P, Iglesias M, Martinez J, Quintanilla M. Urokinase expression and binding activity associated with the transforming growth factor b1-induced migratory and invasive phenotype of mouse epidermal keratinocytes. J Cell Biochem 1999; 74:61-73
1998 Rodriguez JP, Santibañez JF, Martinez J. Soluble factors secreted by PC-3 cells induce structural changes in proteoglycans produced by fetal rat osteoblasts. Tumour Biol 1998; 19:19-29
1998 Depix MS, Martinez J, Santibañez JF, Rovirosa J, San Martin AS, Maccioni R B. The compound 14 keto-stypodiol diacetato from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells. Mol Cell Biochem 1998; 187:191-199
1997 Santibañez JF, Navarro A, Martinez J. Genistein inhibits proliferation and in vitro invasive potential of human tumoral prostatic cell lines. Anticancer Res 1997; 17:1199-1204
1996 Santibañez JF, Silva S, Martinez J. Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralization rate in fetal rat osteoblasts in culture. Br J Cancer 1996; 74:418-422
1996 Martinez J, Silva S, Santibañez JF. Prostate-derived soluble factors block osteoblast differentiation in culture. J Cell Biochem 1996; 61(1):18-25
1995 Santibañez JF, Maccioni RB, Martinez J. The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs. Cell Biochem Function 1995; 13:217-225
1994 Martinez J, Santibañez JF. Surface associated plasminogen activation in leukemic cells : interaction with extra cellular matrix. Eur J Cell Biol 1994; 64:257-263
1993 Santibañez JF, Martinez J. Membrane-associated procollagenase of leukemic cells is activated by urokinase-type plasminogen activator. Leuk Res 1993; 17:1057-1062
1993 Martinez J, Santibañez JF. Extracellular calcium modulates proliferation of factor dependent hemopoietic cells. Cell Biochem Funct 1993; 11:101-105
1992 Martinez J, Santibañez JF, Vial C, Maccioni R. The anti-neoplasic agent estramustine inhibits secretion of interleukin 3 in leukemic cells. Posible role of MAPs. Mol Cell Biochem 1992; 117:165-173
1990 Fernandez M, Martinez J, Minguell J. Collagenase-like activity associated to the leukemic WEHI-3B cell line. Leuk Res 1990; 14(7):661-666
1989 Fernandez M, Barahona C, Martinez J, Minguell J. Changes in collagen synthesis by human bone marrow fibroblasts with progressive subcultivation. Exp Cell Biol 1989; 57:257-263
1987 Martinez J, Minguell J. Triglyceride synthesis by human bone marrow fibroblasts. Exp Hematol 1987; 15:221-225
1982 Carvajal N, Fernandez M, Rodriguez JP, Martinez J. Negative cooperativity in human liver argininosuccinase. Biochim Biophys Acta 1982; 701:408-409
1982 Carvajal N, Acoria M, Rodriguez JP, Fernandez M, Martinez J. Evidence for cooperative effects in human liver arginase. Biochim Biophys Acta 1982; 701:146-148
1978 Carvajal N, Martinez J, Montes de Oca F, Rodriguez JP, Fernandez M. Subunit interactions and immobilised dimers of human liver arginase. Biochim Biophys Acta 1978; 527:1-7
1977 Carvajal N, Martinez J, Fernandez M. Immobilised monomers of human liver arginase. Biochim Biophys Acta 1977; 481:177-183
1996 Rosselot G, Martinez J, Rodriguez JP. Bases celulares del desarrollo del tejido óseo (Cellular basis of bone tissue development). Rev Med Chil 1996; 124(8 Supl):15-20
1996 Martinez J, Rosselot G, Rodriguez JP. Aspectos moleculares del fenómeno osteogénico (Molecular aspects of osteogenic phenomena). Rev Med Chil 1996; 124(8 Supl):21-28
1995 Hidalgo C, Martinez J. La investigación científica en la Universidad de Chile: una mirada contingente (Scientific investigation in the University of Chile. A contingent sight). Anales de la Universidad de Chile 1995; 6º serie (2):25-38
1988 Minguell J, Fernandez M, Tetas M, Martinez J, Bruzzone M, Rodriguez JP. Microambiente hematopoyético : elementos celulares y de matriz extracelular (Bone marrow microenvironment). Arch Biol Med Exp 1988; 21:177-182
2008 Martínez R, Fernández A, Espíndola E, Flores L, Montoya AM, Oviedo E, Peroni A, Vio F, Martinez J, Mendez M, Ivanovic D. The cost of hunger: Social and economic impact of child undernutrition in Central America and the Dominican Republic. Summary Report. Santiago: United Nations, World Food programme (PMA)-Economic Commission for Latin America and the Caribbean (ECLAC); 2008
2007 Martinez R, Fernández A, Espíndola E, Flores L, Montoya AM, Oviedo E, Peroni A, Vio F, Martinez J, Mendez M, Ivanovic D. El costo del hambre. Análisis del impacto social y económico de la desnutrición infantil en América Latina. Resultados del estudio en Centroamérica y República Dominicana. Panorama general (The cost of hunger. Social and economic impact of child undernutrition in Latin America. Results of Central America and the Domican Republic study. General panorama). Santiago: Naciones Unidas, Programa Mundial de Alimentos (PMA)-Comisión Económica para América Latina (CEPAL), División de Desarrollo Social; 2007
2006 Martínez R, Fernández A., editores. Colaboradores: Oviedo E, Espínola E, Flores L, Montoya AM, Peroni A, Vio F, Martinez J, Mendez M, Ivanovic D. Modelo de análisis del impacto social y económico de la desnutrición infantil en América Latina (Model of analysis of the social and economic impact of input undernutrition in Latin America). Santiago: CEPAL, Naciones Unidas, División de Desarrollo Social; 2006 (Serie Manuales; 52).
1995 Vio F, Albala C, Garcia F, Martinez J, Uauy R. Consecuencias de la transición epidemiológica en la salud y nutrición del adulto en Chile. Santiago: INTA; 1995 (Monografía INTA/95/1)
Volver arriba