Metabolismo y regulación Intracelular de metales trazas (Fe, Cu y Zn); Asociación entre el metabolismo de metales trazas con enfermedades cardio-vasculares: Obesidad, diabetes mellitus
Grado Académico
- Doctor en Ciencias, Universidad de Chile, 2002.
- Magister en Ciencias Biológicas, Universidad de Chile, 1996;
- Tecnólogo Médico, Universidad de Chile, 1983.
Unidad Académica
Nutrición Humana
Laboratorio
Áreas de interés
Adjuntos
Publicaciones
| 2010 | Olivares M, Arredondo M, Pizarro F. Hierro (Iron). En: Gil A., editor. Tratado de nutrición. 2ª ed. Madrid: Editorial Médica Panamericana; 2010. v. 1, p. 668-686 |
| 2005 | Olivares M, Castillo Duran C, Arredondo M, Uauy R. Cobre y zinc en nutrición humana (Copper and zinc in human nutrition). En: Gil A., editor. Tratado de nutrición. Madrid: Acción Médica; 2005. vol.1, p.973-996 |
| 2005 | Palomo I, Olivares M, Arredondo M, Pizarro F. Alteraciones del metabolismo del hierro y de la síntesis del Hem (Alterations of iron metabolism and hem synthesis). En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p. 133-159 |
| 2005 | Palomo I, Pizarro F, Olivares M, Arredondo M, Alarcón M, Pombo G. Estudio de laboratorio de anemias nutricionales (Laboratory study of nutritional anemias).En: Palomo I, Pereira J, Palma J., editores. Hematología: Fisiopatología y diagnóstico. Talca: Universidad de Talca; 2005. p.691-700 |
| 1990 | Walter T, Hertrampf E, Arredondo M, Vega V. Gastrointestinal iron losses in infancy: effect of the diet. In: Hercberg S, Galan P, DupinH., editors. Recent knowledge on iron and folate deficiencies in the world. Paris: INSERM; 1990. p. 283-290 (Colloque INSERM; v.197) |
| 2017 | García MI, De la Parra A, Arias C, Arredondo M, Cabello JF. Long-term cognitive functioning in individuals with tyrosinemia type 1 teeated with nitisinone and protein-restricted diet. Mol Genet Metab Rep 2017; 11:12-16 |
| 2017 | Weinborn V, Valenzuela C, Olivares M, Arredondo M, Weill R, Pizarro F. Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans. Food Funct. 2017 May 24; 8(5):1994-1999 |
| 2017 | Mujica V, Orrego R, Pérez J, Romero P, Ovalle P, Zúñiga-Hernández J, Arredondo M, Leiva E. The role of propolis in oxidative stress and lipid metabolism: A randomized controlled trial. Evid Based Complement Alternat Med. 2017; 2017:4272940 |
| 2016 | Andrews M, Leiva E, Arredondo M. Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus. J Trace Elem Med Biol. 2016; 37:25-30 |
| 2016 | Pizarro F, Olivares M, Valenzuela C, Brito A, Weinborn V, Flores S, Arredondo M. The effect of proteins from animal source foods on heme iron bioavailability in humans. Food Chem 2016; 196:733-738 |
| 2015 | Jaramillo A, Briones L, Andrews M, Arredondo M, Olivares M, Brito A, Pizarro F. Effect of phytic acid, tannic acid and pectin on fasting iron bioavailability both in the presence and absence of calcium. J Trace Elem Med Biol 2015; 30:112-117 |
| 2015 | Andrews M, Arredondo M, Olivares M. Glycemic control and oxidative stress markers and their relationship with the thioredoxin interacting protein (TXNIP) gene in type 2 diabetic patients. Nutr Hosp 2015; 31(3):1129-1133 |
| 2015 | Weinborn V, Pizarro F, Olivares M, Brito A, Arredondo M, Flores S, Valenzuela C. The effect of plant proteins derived from cereals and legumes on heme iron absorption. Nutrients 2015; 7(11):8977-8986 |
| 2014 | Arredondo M, Weisstaub SG, Medina M, Suazo M, Guzmán M, Araya M. Assessing chaperone for Zn, Cu-superoxide dismutase as an indicator of copper deficiency in malnourished children. J Trace Elem Med Biol 2014; 28(1):23-27 |
| 2014 | Araya M, Gutiérrez R, Arredondo M. CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes. Biometals 2014; 27(4):645-652 |
| 2014 | Andrews M, Briones L, Jaramillo A, Pizarro F, Arredondo M. Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro caco-2 cell model. Biol Trace Elem Res 2014; 158(1):122-127 |
| 2014 | Arredondo M, Mendiburo MJ, Flores S, Singleton ST, Garrick MD. Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells. Biometals 2014; 27(1):115-123 |
| 2014 | Espinoza A, Morales S, Arredondo M. Effects of acute dietary iron overload in pigs (Sus scrofa) with induced type 2 Diabetes Mellitus. Biol Trace Elem Res 2014; 158(3):342-352 |
| 2014 | Leiva E, Mujica V, Orrego R, Wehinger S, Soto A, Icaza G, Vásquez M, Díaz L, Andrews M, Arredondo M. Subjects with impaired fasting glucose: evolution in a period of 6 years. J Diabetes Res 2014; 2014:710370 |
| 2014 | Andrews M, Arredondo M. Relación entre ferritina, PCRrus y expresion de hepcidina con el riesgo de desarrollo de diabetes mellitus tipo 2 en sujetos obesos (Association between ferritin, high sensitivity c-reactive protein (hsCRP) and relative abundance of Hepcidin mRNA with the risk of type 2 diabetes in obese subjects). Nutr Hosp 2014; 30(3):577-584 |
| 2013 | Leiva E, Mujica V, Sepúlveda P, Guzmán L, Núñez S, Orrego R, Palomo I, Andrews M, Arredondo MA High levels of iron status and oxidative stress in patients with metabolic syndrome. Biol Trace Elem Res 2013; 151(1):1-8 |
| 2013 | Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, González-Billault C, Núñez MT. Inflammation alters the expression of DMT1, FPN1 and hepcidin and causes iron accumulation in central nervous system cells. J Neurochem 2013; 126(4):541-549 |
| 2013 | Ruz M, Carrasco F, Rojas P, Codoceo J, Inostroza J, Basfi-fer K, Valencia A, Vásquez K, Galgani J, Pérez A, López G, Arredondo M, Perez-Bravo F. Zinc as a potential coadjuvant in therapy for type 2 diabetes. Food Nutr Bull 2013; 34(2):215-221 |
| 2013 | Arredondo M, Mendiburo MJ, Flores S, Singleton ST, Garrick MD. Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells. Biometals 2013 Dec 11 |
| 2012 | Villarroel P, Le Blanc S, Arredondo M. Interleukin-6 and lipopolysaccharide modulate hepcidin mRNA expression by hepg2 cells. Biol Trace Elem Res 2012; 150(1-3):496-501 |
| 2012 | Valencia E, Codner E, Salas-Pérez F, Pizarro C, Carrasco PE, Arredondo M, Pérez-Bravo F. High glucose concentration in T1D patients modulates apoptotic protein expression: Down regulation of bax and fas and up regulation of xiap. Hum Immunol 2012; 73(8):801-804 |
| 2012 | Le Blanc S, Garrick MD, Arredondo M. Heme Carrier Protein 1 (HCP1) transports heme and is involved in heme-Fe metabolism. Am J Physiol Cell Physiol 2012 ; 302(12):C1780-1785 |
| 2012 | Le Blanc S, Villarroel P, Candia V, Gavilán N, Soto N, Pérez-Bravo F, Arredondo M. Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity. Biometals 2012; 25(4):725-735 |
| 2012 | Andrews M, Arredondo M. Hepatic and adipocyte cells respond differentially to iron overload, hypoxic and inflammatory challenge. Biometals 2012; 25(4):749-759 |
| 2012 | Araya M, Núñez H, Pavez L, Arredondo M, Méndez M, Cisternas F, Pizarro F, Sierralta W, Uauy R, González M. Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr 2012; 142(2):233-237 |
| 2012 | Andrews M, Arredondo M. Ferritin levels and hepcidin mRNA expression in peripheral mononuclear cells from anemic type 2 diabetic patients. Biol Trace Elem Res 2012; 149(1):1-4 |
| 2012 | Gaitán DA, Flores S, Pizarro F, Olivares M, Suazo M, Arredondo M. The effect of calcium on non-heme iron uptake, efflux, and transport in intestinal-like epithelial cells (Caco-2 cells). Biol Trace Elem Res 2012; 145(3):300-303 |
| 2012 | Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Iron, copper, and zinc transport: Inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res 2012; 146(2):281-286 |
| 2012 | Araya M, Andrews M, Pizarro F, Arredondo M. Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults. Biometals 2012; 25(2):383-391 |
| 2011 | Leiva E, Mujica V, Brito K, Palomo I, Orrego R, Moore-Carrasco R, Vásquez M, Guzmán L, Nuñez S, Díaz N, Icaza G, Arredondo M. High levels of hsCRP are associated with carbohydrate metabolism disorder. J Clin Lab Anal 2011; 25(6):375-381 |
| 2011 | Gaitán D, Flores S, Saavedra P, Miranda C, Olivares M, Arredondo M, López de Romaña D, Lönnerdal B, Pizarro F. Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women. J Nutr 2011; 141(9):1652-1656 |
| 2011 | Mendiburo MJ, Le Blanc S, Espinoza A, Pizarro F, Arredondo M. Transepithelial heme-iron transport: effect of heme oxygenase overexpression. Eur J Nutr 2011; 50(5):363-371 |
| 2011 | Arredondo M, Fuentes M, Jorquera D, Candia V, Carrasco E, Leiva E, Mujica V, Hertrampf E, Pérez Bravo F. Cross-talk between body iron stores and diabetes: Iron stores are associated with activity and microsatellite polymorphism of the heme oxygenase and type 2 diabetes. Biol Trace Elem Res 2011; 143(2):625-636 |
| 2011 | Villarroel P, Flores S, Pizarro F, de Romaña DL, Arredondo M. Effect of dietary protein on heme iron uptake by Caco-2 cells. Eur J Nutr. 2011; 50(8):637-643 |
| 2011 | Arredondo M, Espinoza A, Pizarro F, Araya M. Searching for specific responses to copper exposure: An in vitro copper challenge in peripheral mononuclear cells. Biol Trace Elem Res 2011; 142(3):407-414 |
| 2010 | Arredondo M, Núñez H, López G, Pizarro F, Ayala M, Araya M. Influence of estrogens on copper indicators: In vivo and in vitro studies. Biol Trace Elem Res 2010; 134:252-264 |
| 2009 | Barbeito AG, Garringer HJ, Baraibar MA, Gao X, Arredondo M, Núñez MT, Smith MA, Ghetti B, Vidal R. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. J Neurochem 2009; 109(4):1067-1078 |
| 2008 | Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson’s disease. Proc Natl Acad Sci USA 2008; 105(47):18578-18583 |
| 2008 | Mujica V, Leiva E, Icaza G, Diaz N, Arredondo M,; Moore R, Orrego R, Vásquez M, Palomo I. Evaluation of metabolic syndrome in adults of Talca City, Chile. Nutr J 2008; 7:14 (20 p.) |
| 2008 | Arredondo M, Kloosterman J, Núñez S, Segovia F, Candia V, Flores S, Le Blanc S, Olivares M, Pizarro F. Heme Iron Uptake by Caco-2 Cells is a Saturable, Temperature Sensitive and Modulated by Extracellular pH and Potassium. Biol Trace Elem Res 2008; 125(2):109-119 |
| 2008 | Suazo M, Olivares F, Mendez MA, Pulgar R, Prohaska JR, Arredondo M, Pizarro F, Olivares M, Araya M, Gonzalez M. CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration. J Nutr Biochem 2008; 19(4):269-274 |
| 2008 | Arredondo M, Gonzalez M, Olivares M, Pizarro F, Araya M. Ceruloplasmin, an indicator of copper status. Biol Trace Elem Res 2008; 123(1-3):261-269 |
| 2008 | Núñez H, Araya M, Cisternas F, Arredondo M, Mendez M, Pizarro F, Ortiz A, Ortiz R, Olivares M. Blood biochemical indicators in young and adult Cebus apella of both sexes. J Med Primatol 2008;37(1):12-17 |
| 2008 | Ayala M, Pizarro F, Mendez MA, Arredondo M, Araya M. Copper and liver function indicators vary depending on the female hormonal cycle and serum hormone binding globulin (SHBG) concentration in healthy women. Biol Trace Elem Res 2008; 121(1):9-15 |
| 2007 | Leiva E, Mujica V, Elematore I, Orrego R, Díaz G, Prieto M, Arredondo M. Relationship between Apolipoprotein E polymorphism and nephropathy in type-2 diabetic patients. Diabetes Res Clin Pract 2007; 78(2):196-201 |
| 2007 | Arredondo M, Jorquera D, Carrasco E, Albala C, Hertrampf E. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. Am J Clin Nutr 2007; 86(5):1347-1353 |
| 2006 | Arredondo M, Tapia V, Rojas A, Aguirre P, Reyes F, Marzolo MP, Nuñez MT. Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells. Biometals 2006; 19(4):379-388 |
| 2006 | Arredondo M, Salvat V, Pizarro F, Olivares M. Smaller iron particle size improves bioavailability of hydrogen-reduced iron fortified bread. Nutr Res 2006; 26:235-239 |
| 2005 | Araya M, Kelleher SL, Arredondo M, Sierralta W, Vial MT, Uauy R, Lonnerdal B. Effects of chronic copper exposure during early life in rhesus monkeys. Am J Clin Nutr 2005; 81(5):1065-1071 |
| 2005 | Leiva E, Mujica V, Orrego R, Prieto M, Arredondo M. Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile. Diabetes Res Clin Pract 2005; 68(3):244-249 |
| 2005 | Aguirre P, Mena N, Tapia V, Arredondo M, Nuñez MT. Iron homeostasis in neuronal cells: a role for IREG1. BMC Neurosci 2005; 6(1):3 |
| 2005 | Arredondo M, Nuñez MT. Iron and copper metabolism. Mol Aspects Med 2005; 26(4-5):313-327 |
| 2005 | Cisternas F, Tapia G, Arredondo M, Cartier-Ugarte D, Romanque P, Sierralta W, Vial M, Videla L, Araya M. Early histological and functional effects of chronic copper exposure in rat liver. Biometals 2005; 18(5):541-551 |
| 2005 | Muñoz C, Lopez M, Olivares M, Pizarro F, Arredondo M, Araya M. Differential response of interleukin-2 production to chronic copper supplementation in healthy humans. Eur Cytokine Netw 2005; 16(4):261-265 |
| 2004 | Mazariegos DI, Pizarro F, Olivares M, Nuñez MT, Arredondo M. The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe ascorbate in caco-2 cells are similar. J Nutr 2004; 134:395-398 |
| 2004 | Arredondo M, Cambiazo V, Tapia L, Nuñez MT, Uauy R, Gonzalez M. Copper overload affects copper an iron metabolism in HepG2 cells. Am J Physiol Gastrointest Liver Physiol 2004; 287(1):G27-32 |
| 2003 | Pizarro F, Olivares M, Hertrampf E, Arredondo M. Reply to O. Pineda: Iron bis-glycine chelate competes for the nonheme-iron absorption pathway. Am J Clin Nutr 2003; 78:493-497 (Letter) |
| 2003 | Arredondo M, Muñoz P, Mura C, Nuñez MT. DMT1, a physiologically relevant apical Cu+1 transporter of intestinal cells. Am J Physiol Cell Physiol 2003; 284:C1525-C1530 |
| 2003 | Nuñez MT, Nuñez C, Tapia V, Muñoz P, Mazariegos D, Arredondo M, Mura C, Maccioni R. Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1. Biometals 2003; 16:83-90 |
| 2003 | Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M. Heme-iron absorption is saturable by heme-iron dose in women. J Nutr 2003; 133:2214-2217 |
| 2002 | Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M, Letelier A, Gidi V. Iron bis-glycine chelate competes for the nonheme-iron absorption pathway. Am J Clin Nutr 2002; 76(3):577-581 |
| 2001 | Arredondo M, Muñoz P, Mura C, Nuñez M. HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells. FASEB J 2001; 15(7):1276-1278 |
| 2000 | Arredondo M, Uauy R, Gonzalez M. Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure. Biochim Biophys Acta 2000; 1474:169-176 |
| 1999 | Olivares M, Pizarro F, Walter T, Arredondo M, Hertrampf E. Bioavailability of iron supplements consumed daily is not different from that of iron supplements consumed weekly. Nutr Res 1999; 19(2):179-190 |
| 1997 | Arredondo M, Orellana A, Garate M, Nuñez MT. Intracellular iron regulates iron absorption and IRP activity in intestinal ephitelial (Caco-2) cells. Am J Physiol 1997; 273:G275-G280 |
| 1996 | Tapia V, Arredondo M, Nuñez MT. The regulation of iron absorption by cultured instestinal epithelia (Caco-2) cell monolayers with varied Fe status. Am J Physiol 1996; 271:G443-G447 |
| 1996 | Nuñez MT, Tapia V, Arredondo M. Intestinal epithelia cell (Caco-2) acquire iron through the basolateral endocytosis of transferrin. J Nutr 1996; 126(9):2151-2158 |
| 1993 | Walter T, Dallman PR, Pizarro F, Veloso L, Peña G, Bartholomey S, Hertrampf E, Olivares M, Letelier A, Arredondo M. Effectiveness of iron-fortified infant cereal in prevention of iron deficiency anemia. Pediatrics 1993; 91:976-982 |
| 2013 | Villarroel P, Arredondo M, Olivares M. Anemia de las enfermedades crónicas asociada a obesidad: Papel de la hepcidina como mediador central (Hepcidin as a central mediator of anemia of chronic diseases associated with obesity). Rev Méd Chil 2013; 141(7):887-894 |
| 2012 | Angel B, Codner E, Arredondo M, Salas F, Pizarro C, Pérez Bravo F. Expresión disminuida de caspasa 3 asociada al polimorfismo del gen del antígeno-4 asociado a linfocito T-citotóxico (CTLA4) en pacientes chilenos con diabetes tipo 1 (Decreased caspase 3 expression and cytotoxic T lymphocyte antigen-4 polymorphism in Chilean patients with type 1 diabetes). Rev Med Chil 2012; 140(9):1109-1115 |
| 2012 | Andrews M, Soto N, Arredondo M. Efecto de metformina sobre la expresión del factor de necrosis tumoral-α, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2 (Effect of metformin on the expression of tumor necrosis factor-α, Toll like receptors 2/4 and C reactive protein in obese type-2 diabetic patients). Rev Méd Chil 2012: 140(11):1377-1382 |
| 2008 | Valenzuela C, Letelier A, Olivares M, Arredondo M, Pizarro F. Determinación de hierro, zinc y cobre en carne de bovino (Iron, zinc and copper content of cow meat). Rev Chil Nutr 2008; 35(2):139-146 |
| 2006 | Gaitan D, Olivares M, Arredondo M, Pizarro F. Biodisponibilidad de hierro en humanos (Iron bioavailability in humans). Rev Chil Nutr 2006; 33(2):142-148 |
| 2006 | Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M. Understanding copper homeostasis in humans and copper effects on health. Biol Res 2006;39(1):183-187 |
| 2006 | Mendiburo MJ, Flores S, Pizarro F, Arredondo M. Heme oxygenase 1 overexpression increases iron fluxes in caco-2 cells. Biol Res 2006;39(1):195-197 |
| 2006 | Aguirre P, Mena N, Tapia V, Rojas A, Arredondo M, Nuñez MT. Antioxidant responses of cortex neurons to iron loading. Biol Res 2006;39(1):103-104 |
| 2006 | Arredondo M, Martinez R, Nuñez MT, Ruz M, Olivares M. Inhibition of iron and copper uptake by iron, copper and zinc. Biol Res 2006; 39(1):95-102 |
| 2000 | Olivares M, Pizarro F, Hertrampf E, Walter T, Arredondo M, Letelier A. Fortificación de alimentos con hierro en Chile (Iron fortification of foods in Chile). Rev Chil Nutr 2000; 27:340-344 |
| 2000 | Nuñez M, Garate M, Arredondo M, Tapia V, Muñoz P. The cellular mechanisms of body iron homeostasis. Biol Res 2000; 33:133-142 |
| 1992 | Arredondo M, Pizarro F, Walter T, Hertrampf E. Determinación de ferritina sérica por ELISA (Serum ferritin assay by ELISA). Rev Chil Nutr 1992; 20:43-50 |
| 1990 | Arredondo M, Herrera G, Silva G, Muñoz M, Ziede J, Alfaro L. Lípidos séricos en hipertensos y/o diabéticos de la ciudad de Antofagasta (Lipids in hypertension patients and/or diabetics from Antofagasta city). Rev Chil Tecnol Med 1990; 13(2):650-654 |
| 1988 | Arredondo M, Pizarro F, Walter T, Hertrampf E. Determinación cuantitativa de hemoglobina fecal por fluorometría (Quantitative determination of fecal hemoglobin for fluorometrics). Rev Chil Tecnol Med 1988; 11:549-554 |
| 1985 | Silva G, Acuña O, Arredondo M, Vega R, Muñoz M. Efecto crónico de Li en la presión arterial de rata (Lithium chronic effect in rat arterial pressure). Rev Chil Tecnol Med 1985; 8(1):319-324 |
| 1984 | Arredondo M, Alfaro L, Silva G, Mamani T. Determinación de calicreína urinaria (C.U.) por método indirecto en mamíferos (Urinary kallikrein determination by indirect method in mammals). Rev Chil Tecnol Med 1984; 7(1-2):249-255 |