El estudio de los mecanismos moleculares de la acción de los glucocortioides y su relación con el desarrollo de enfermedades crónicas asociadas a la nutrición.
Grado Académico
- Doctor en Bioquímica, Universidad de Chile
- Químico Farmacéutico, Universidad de Chile
Unidad Académica
Nutrición Humana
Laboratorio
Adjuntos
| 2014 | Troncoso R, Verdejo HE, Quiroga C, Pedrozo Z, Corbalan R, García L. Autophagy in the onset of atrial fibrillation. AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Chapter 12. Autophay in the Onset of Atrial Fibrillation .Elsevier. Volume 5, 2014. |
| 2012 | Troncoso R, Vásquez-Trincado C, del Campo A, Gatica D, Morales P, Paredes F, Gutierrez T, Lopez-Crisosto C, Torrealba N, Garcia L, Diaz-Araya G, Battiprolu PK, Nemchenko A, Ferdous A, Gillette T, Hill JA, Lavandero S. Chapter 9. Regulation of autophagy by Insulin/IGF-1 signaling pathways. Autophagy: Principles, Regulation and Roles in Disease. Nova Publishers. 181-194, 2012. |
| 2018 | Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, Del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R. Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. Mol Cell Endocrinol. 2018; 461:277-283 |
| 2017 | Tenorio B, Jiménez T, Barrera G, Hirsch S, De la Maza MP, Troncoso R, Farías MB, Rodríguez JM, Bunout D. Irisin is weakly associated with usual physical activity in young overweight women. Nutr Hosp. 2017; 34(3):688-692 |
| 2017 | Peña-Oyarzun D, Troncoso R, Kretschmar C, Hernando C, Budini M, Morselli E, Lavandero S, Criollo A. Hyperosmotic stress stimulates autophagy via polycystin-2. Oncotarget. 2017; 8(34):55984-55997 |
| 2016 | Shaikh S, Troncoso R, Criollo A, Bravo-Sagua R, Morselli E, Garcia L, Quest AF, Cifuentes M, Hill JA, Lavandero S. Regulation of cardiomyocyte autophagy by calcium. Am J Physiol Endocrinol Metab 2016; 310:E587-E596 |
| 2016 | Campos T, Ziehe J, Fuentes-Villalobos F, Riquelme O, Peña D, Troncoso R, Lavandero S, Morin V, Pincheira R, Castro AF. Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival. Biochim Biophys Acta 2016; 1863(6 Pt A):1200-1207 |
| 2016 | Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A… et al. …Troncoso R. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12(1):1-222 |
| 2016 | Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med 2016; 90:206-218 |
| 2016 | Verdejo HE, Zalaquett R, Del Campo A, García L, Troncoso R, Marin A, Chiong M, Castro P, Lavandero S, Gabrielli L, Corbalán R. Atrial systolic function assessed by speckle tracking echocardiography is a good predictor of post-operative atrial fibrillation in elderly patients. Echocardiography 2016; 33(2):242-248 |
| 2016 | Rodriguez JM, Monsalves-Alvarez M, Henriquez S, Llanos MN, Troncoso R. Glucocorticoid resistance in chronic diseases. Steroids. 2016; 115:182-192 |
| 2016 | Pizarro M, Troncoso R, Martínez GJ, Chiong M, Castro PF, Lavandero S. Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity. Toxicology. 2016; 370:41-48 |
| 2015 | Oyarzún AP, Westermeier F, Pennanen C, López-Crisosto C, Parra V, Sotomayor-Flores C, Sánchez G, Pedrozo Z, Troncoso R, Lavandero S. FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes. Biochem Pharmacol 2015;98(1):92-101 |
| 2015 | Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med; 90:206-218 |
| 2015 | Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. Unsaturated fatty acids induce non-canonical autophagy. EMBO J 2015; 34(8):1025-41 |
| 2014 | Parra V, Verdejo HE, Iglewski M, del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes 2014; 63(1):75-88 |
| 2014 | del Campo A, Parra V, Gutiérrez T, Morales PE, López-Crisosto C,1 Vásquez-Trincado C, Bravo R, Verdejo HE, Contreras-Ferrat A, Troncoso R, Chiong M, Lavandero S. Mitochondrial fragmentation impairs insulin-dependent glucose uptake modulating Akt activity through mitochondrial Ca2+ uptake. Am J Physiol Endocrinol Metab 2014; 306(1):E1-E13 |
| 2014 | Gutierrez T, Parra V, Troncoso R, Pennanen C, Contreras-Ferrat A, Vasquez-Trincado C, Morales PE, Lopez-Crisosto C, Sotomayor-Flores C, Chiong M, Rothermel BA, Lavandero S. Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocyte. Cell Commun Signal 2014;12(1):68 |
| 2014 | Troncoso R, Paredes F, Parra V, Gatica D, Vázquez-Trincado C, Quiroga C, Bravo-Sagua R, Lopez-Crisosto C, Rodriguez AE, Oyarzún AP, Kroemer G, Lavandero S. Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance. Cell Cycle 2014;13(14):2281-95 |
| 2014 | Troncoso R, Ibarra C, Vicencio JM, Jaimovich E, Lavandero S. New insights into IGF-1 signaling in the heart. Trends Endocrinol Metab 2014; 25(3):128-137 |
| 2014 | Bravo R, Torrealba N, Paredes F, Morales PE, Pennanen C, López-Crisosto C, Troncoso R, Chiong M, Simmen T, Quest AF, Lavandero S. Organelle communication: signaling crossroads of homeostasis and disease. Int J Biochem Cell Biol 2014; 50:55-59 |
| 2014 | Zepeda R, Kuzmicic J, Parra V, Troncoso R, Penannen C, Riquelme JA, Pedrozo Z, Chiong M, Sanchez G, Lavandero S. Drp1 loss-of-function reduces cardiomyocyte oxygen-dependence protecting the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol 2014; 63(6):477-487 |
| 2013 | Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: Concepts, controversies and perspectives. Autophagy 2013; 3(9):1455-1466 |
| 2013 | Quiroga C, Gatica D, Paredes F, Bravo-Sagua R, Troncoso R, Pedrozo Z, Rodriguez AE, Toro B, Chiong M, Vicencio JM, Hetz C, Lavandero S. Herp depletion protects from protein aggregation by up-regulation of autophagy. Biochim Biophys Acta 2013; 1833(2):3295-3305 |
| 2013 | Troncoso R, Díaz-Elizondo J, Espinoza S, Navarro-Marquez M, Oyarzún AP, Riquelme JA, Garcia-Carvajal I, Díaz-Araya G, García L, Hill JA, Lavandero S. Regulation of cardiac autophagy by insulin-like growth factor 1. IUBMB Life 2013; 65(7):593-601. |
| 2012 | Verdejo HE, del Campo A, Troncoso R, Gutierrez T, Toro B, Quiroga C, Munoz JP, Garcia L, Castro PF, Lavandero S. Mitochondria, myocardial remodeling and cardiovascular disease. Curr Hypertens Rep 2012; 14(6):532-539 |
| 2012 | Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, Lavandero S. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res 2012; 93(2):320-329 |
| 2012 | Ayala P, Montenegro J, Vivar R, Letelier A, Aránguiz-Urroz P, Copaja M, Pivet D, Humeres C, Troncoso R, Vicencio JM, Lavandero S, Díaz-Araya G. Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp Mol Pathol 2012; 92(1):97-104 |
| 2011 | Chiong M, Wang ZV, Pedrozo Z, Cao DJ, Troncoso R, Ibacache M, Criollo A, Nemchenko A, Hill JA, Lavandero S. Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis 2011; 22(2):e244. |
| 2011 | Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 2011; 124(13):2143-2152 |
| 2011 | Aranguiz-Urroz P, Canales J, Copaja M, Troncoso R, Vicencio JM, Carrillo C, Lara H, Lavandero S, Díaz-Araya G. β2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation. Biochim Biophys Acta 2011; 1812(1):23-31 |
| 2010 | Marambio P, Toro B, Sanhueza C, Troncoso R, Parra V, Verdejo H, García L, Quiroga C, Munafo D, Díaz-Elizondo J, Bravo R, González MJ, Diaz-Araya G, Pedrozo Z, Chiong M, Colombo MI, Lavandero S. Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes. Biochim Biophys Acta 2010; 1802(6):509-518 |
| 2010 | Muñoz JP, Chiong M, García L, Troncoso R, Toro B, Pedrozo Z, Diaz-Elizondo J, Salas D, Parra V, Núñez MT, Hidalgo C, Lavandero S. Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide. Free Radic Biol Med 2010; 48(4):526-534 |
| 2010 | Bittner A, Alcaíno H, Castro PF, Pérez O, Corbalán R, Troncoso R, Chiong M, Mellado R, Moraga F, Zanolli D, Winter JL, Zamorano JJ, Díaz-Araya G, Lavandero S. Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome. Int J Cardiol 2010; 143(1):98-100. |
| 2009 | Troncoso R, Moraga F, Castro PF, Chiong M, Mellado RM, Roldán J, Díaz-Araya G, Vukasovic JL, Greig D, Lavandero S. Gln27→Glu β2-adrenergic receptor polymorphism in heart failure patients: differential clinical and oxidative response to carvedilol. Basic Clin Pharmacol Toxicol 2009; 104(5):374-378. |
| 2009 | Aránguiz-Urroz P, Soto D, Contreras A, Troncoso R, Chiong M, Montenegro J, Venegas D, Smolic C, Ayala P, Thomas WG, Lavandero S, Díaz-Araya G. Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II. Am J Hypertens 2009; 22(5):569-576 |
| 2009 | Ribeiro CH, Molina MC, Aguilar L, Rodríguez M, Maldonado I, Valck C, Martínez R, González C, Troncoso R, Lavandero S, Gingras A, Schwaeble W, Ferreira A. Does Trypanosoma cruzi calreticulin have a role in Chagas’ disease autoimmunity?. Mol Immunol 2009; 46(6):1092-1099 |
| 2009 | Eisner V, Criollo A, Quiroga C, Olea-Azar C, Santibañez JF, Troncoso R, Chiong M, Díaz-Araya G, Foncea R, Lavandero S. Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett 2006; 580(18):4495-4500. |
| 2009 | Castro PF, Mc-Nab P, Bittner A, Greig D, Quintana JC, Vergara I, Corbalan R, Vukasovic JL, Chiong M, Copaja M, Diaz-Araya G, Troncoso R, Alcaino H, Lavandero S. Effects of carvedilol upon intra and interventricular syncrony in patients with chronic heart failure. Am J Cardiol 2005; 96:267-269. |
| 2004 | Castro P, Perez O, Greig D, Diaz-Araya G, Moraga F, Chiong M, Troncoso R, Padilla I, Vukasovic JL, Corbalan R, Lavandero S. Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure. Rev Esp Cardiol 2004; 57:1053-1058 |
| 2010 | Castro P, Gabrielli L, Verdejo H, Greig D, Mellado R, Concepción R, Sepúlveda L, Vukasovic JL, García L, Pizarro M, Pivet D, Carrillo C, Tapia F, Navarro M, Troncoso R, Baraona F, Llevaneras S, Hernández C, Godoy I, Jalil JE, Quintana JC, Orellana P, Chiong M, Lavandero S. Heart energy metabolism and its role in the treatment of heart failure]. Rev Med Chil. 2010 Aug;138(8):1028-39. |
| 2010 | Castro P, Gabrielli L, Verdejo H, Greig D, Mellado R, Concepción R, Sepúlveda L, Vukasovic JL, García L, Pizarro M, Pivet D, Carrillo C, Tapia F, Navarro M, Troncoso R, Baraona F, Llevaneras S, Hernández C, Godoy I, Jalil JE, Quintana JC, Orellana P, Chiong M, Lavandero S. Heart energy metabolism and its role in the treatment of heart failure]. Rev Med Chil. 2010 Aug;138(8):1028-39. |
| 2008 | Moraga F, Troncoso R, Mellado RM, Díaz-Araya G, Vukasovic JL, Greig D, Pérez O, García L, Roldán J, Ocaranza MP, Jalil J, Chiong M, Castro P. Interacción entre los polimorfismos del receptor β1 y β2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica. Rev Med Chil. 136(11):1371-80, 2008. |
| 2006 | Aránguiz P, Contreras A, Rojas D, Troncoso R, Marambio P, Toro B, Sanhueza C, Penannen C, Díaz-Elizondo J, Parra V, Chiong M, Díaz-Araya G, Lavandero S. Autofagia del cardiomiocito: ¿un nuevo mecanismo de adaptación al estrés o de muerte celular?. Rev Chil Cardiol 25:331-338, 2006. |
| 2005 | Castro P, Lavandero S, Greig D, Copaja M, Alcaíno H, Troncoso R, Chiong M, Mellado R, Pérez O, Vukasovic JL, Díaz-Araya G, Corbalán R, Ocaranza MP, Jalil J. Polimorfismos de los receptores ß-adrenérgicos determinan el riesgo y etiología de la insuficiencia cardíaca. Boletín de la Escuela de Medicina 20: 12-18, 2005. |
| 2005 | Castro P, Greig D, Copaja M, Alcaíno H, Troncoso R, Chiong M, Mellado R, Pérez O, Vukasovic JL, Díaz-Araya G, Corbalán R, Ocaranza MP, Jalil J, Lavandero S. Polimorfismos de los receptores β-adrenérgicos y su relación con el riesgo de insuficiencia cardiaca, etiología y prevalencia de infarto al miocardio. Rev Chil Cardiol 24: 38-47, 2005. |
| 2005 | Castro P, Mc-Nab P, Quintana JC, Bittner A, Greig D, Vergara I, Vukasovic JL, Corbalan R, Copaja M, Diaz-Araya G, Chiong M, Troncoso R, Alcaino H, Lavandero S. Efecto del carvedilol sobre la sincronía ventricular en pacientes con insuficiencia cardiaca congestiva. Rev Chil Cardiol 24: 132-137, 2005. |
| 2005 | Bittner A, Castro P, Pérez O, Corbalán R, Troncoso R, Chiong M, Díaz-Araya, Vicencio JM, Moraga F, Zanolli D, Winter JL, Zamorano JJ, Lavandero S. Inflamación y estrés oxidativo en el síndrome coronario agudo: ¿dos fenómenos relacionados?. Boletín de la Escuela de Medicina. 20: 6-11, 2005. |